| Entry |
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| Name |
Colchicine (JP17/USP);
Colchicine (TN)
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| Product |
|
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| Generic |
|
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| Formula |
C22H25NO6
|
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| Exact mass |
399.1682
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| Mol weight |
399.437
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| Structure |
   |
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| Simcomp |
 |
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| Source |
Colchicum autumnale [TAX: 45005]
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| Class |
Metabolizing enzyme substrate
DG02913 CYP3A4 substrate
Transporter substrate
DG01665 ABCB1 (P-GP) substrate
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| Remark |
| Therapeutic category: | 3941 |
| Product (mixture): | D11574<US> |
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| Efficacy |
Gout suppressant, Leukocyte (neutrophil) migration inhibitor, Tubulin polymerization inhibitor |
|---|
| Disease |
Gout flares [DS: H01532] Familial mediterranean fever [DS: H00288] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
Transporter: ABCB1 [HSA: 5243]
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| Interaction |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M04 ANTIGOUT PREPARATIONS
M04A ANTIGOUT PREPARATIONS
M04AC Preparations with no effect on uric acid metabolism
M04AC01 Colchicine
D00570 Colchicine (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
Antigout Agents
Colchicine
D00570 Colchicine (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
394 Gout preparations
3941 Colchicines
D00570 Colchicine (JP17/USP)
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D00570 Colchicine (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00570 Colchicine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 C1x C 24.2475 -17.8137
2 C8y C 23.4044 -16.6895
3 C8y C 23.7557 -15.3545
4 C1x C 25.6528 -17.8137
5 C2y C 26.2852 -15.4247
6 C1y C 26.5662 -16.7597
7 C8y C 22.7018 -14.3708
8 C8y C 21.3668 -14.7924
9 C8y C 21.0155 -16.1274
10 C8x C 22.0695 -17.1111
11 O2a O 22.9829 -12.9655
12 O2a O 20.3832 -13.8087
13 O2a O 19.6805 -16.5489
14 C2y C 25.0493 -14.7557
15 C2x C 24.7813 -13.3322
16 C2x C 25.7259 -12.3957
17 C2y C 27.1392 -12.3715
18 C5x C 27.9503 -13.5297
19 C2x C 27.5618 -14.8375
20 C1a C 18.6440 -15.6000
21 C1a C 20.7468 -12.4513
22 C1a C 24.3140 -12.5152
23 O5x O 29.3583 -13.5117
24 O2a O 27.7924 -11.1650
25 C1a C 29.1660 -11.1268
26 N1b N 27.9266 -17.1119
27 C5a C 29.1058 -16.3874
28 C1a C 30.3325 -17.0465
29 O5a O 29.1329 -14.9842
BOND 31
1 1 4 1
2 2 3 1
3 4 6 1
4 1 2 1
5 5 6 1
6 3 7 2
7 7 8 1
8 8 9 2
9 9 10 1
10 2 10 2
11 7 11 1
12 8 12 1
13 9 13 1
14 16 17 2
15 17 18 1
16 15 16 1
17 5 19 2
18 14 15 2
19 18 19 1
20 3 14 1
21 14 5 1
22 13 20 1
23 12 21 1
24 11 22 1
25 18 23 2
26 17 24 1
27 24 25 1
28 6 26 1 #Up
29 26 27 1
30 27 28 1
31 27 29 2
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