KEGG   DRUG: Bupropion hydrochloride
Entry
D00817                      Drug                                   
Name
Bupropion hydrochloride (JAN/USP);
Wellbutrin (TN);
Zyban (TN)
Product
FORFIVO (Almatica Pharma), FORFIVO (TWi Pharmaceuticals), WELLBUTRIN (Bausch Health US LLC), WELLBUTRIN (GlaxoSmithKline LLC)
  Generic
BUPROPION (A-S Medication Solutions), BUPROPION (Bryant Ranch Prepack), BUPROPION (NCS HealthCare of KY), BUPROPION (Northwind Pharmaceuticals), BUPROPION (Proficient Rx LP), BUPROPION (Proficient Rx LP), BUPROPION (REMEDYREPACK), BUPROPION (Solco Healthcare US LLC), BUPROPION (Zydus Lifesciences Limited), BUPROPION (Zydus Pharmaceuticals USA), BUPROPION HCL (Direct_Rx), BUPROPION HCL ER (XL) (Direct_RX), BUPROPION HCL ER (XL) (Direct_Rx), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (Accord Healthcare), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), BUPROPION HYDROCHLORIDE (Alembic Pharmaceuticals Limited), BUPROPION HYDROCHLORIDE (Alembic Pharmaceuticals), BUPROPION HYDROCHLORIDE (Alvogen), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), BUPROPION HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Apnar Pharma LP), BUPROPION HYDROCHLORIDE (Apotex Corp), BUPROPION HYDROCHLORIDE (Asclemed USA), BUPROPION HYDROCHLORIDE (Aurobindo Pharma Limited), BUPROPION HYDROCHLORIDE (AvKARE), BUPROPION HYDROCHLORIDE (AvPAK), BUPROPION HYDROCHLORIDE (AvPAK), BUPROPION HYDROCHLORIDE (BluePoint Laboratories), BUPROPION HYDROCHLORIDE (BluePoint Laboratories), BUPROPION HYDROCHLORIDE (BluePoint Laboratories), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (CIPLA USA INC.,), BUPROPION HYDROCHLORIDE (CIPLA USA INC.,), BUPROPION HYDROCHLORIDE (Cadila Pharmaceuticals Limited), BUPROPION HYDROCHLORIDE (Camber Pharmaceuticals), BUPROPION HYDROCHLORIDE (Cardinal Health 107), BUPROPION HYDROCHLORIDE (Cardinal Health 107), BUPROPION HYDROCHLORIDE (Cardinal Health 107), BUPROPION HYDROCHLORIDE (Chartwell RX), BUPROPION HYDROCHLORIDE (Cipla USA.), BUPROPION HYDROCHLORIDE (DIRECT RX), BUPROPION HYDROCHLORIDE (Direct_Rx), BUPROPION HYDROCHLORIDE (Direct_Rx), BUPROPION HYDROCHLORIDE (Dr Reddys Laboratories), BUPROPION HYDROCHLORIDE (Dr. Reddy's Laboratories), BUPROPION HYDROCHLORIDE (Dr. Reddy's Laboratories), BUPROPION HYDROCHLORIDE (Eon Labs), BUPROPION HYDROCHLORIDE (Epic Pharma LLC), BUPROPION HYDROCHLORIDE (Epic Pharma), BUPROPION HYDROCHLORIDE (Epic Pharma), BUPROPION HYDROCHLORIDE (Epic Pharma), BUPROPION HYDROCHLORIDE (Epic Pharma), BUPROPION HYDROCHLORIDE (Exelan Pharmaceuticals), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Granules Pharmaceuticals), BUPROPION HYDROCHLORIDE (Graviti Pharmaceuticals Private Limited), BUPROPION HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BUPROPION HYDROCHLORIDE (Lupin Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE (McKesson Corporation DBA SKY Packaging), BUPROPION HYDROCHLORIDE (Medsource Pharmaceuticals), BUPROPION HYDROCHLORIDE (Medsource Pharmaceuticals), BUPROPION HYDROCHLORIDE (Micro Labs Limited), BUPROPION HYDROCHLORIDE (Modavar Pharmaceuticals LLC), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (Northwind Pharmaceuticals), BUPROPION HYDROCHLORIDE (Northwind Pharmaceuticals), BUPROPION HYDROCHLORIDE (Northwind Pharmaceuticals), BUPROPION HYDROCHLORIDE (Northwind Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmacueticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (Par Pharmaceutical), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (Quallent Pharmaceuticals Health LLC), BUPROPION HYDROCHLORIDE (RADHA PHARMACEUTICALS), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (RPK Pharmaceuticals), BUPROPION HYDROCHLORIDE (RPK Pharmaceuticals), BUPROPION HYDROCHLORIDE (RPK Pharmaceuticals), BUPROPION HYDROCHLORIDE (RPK Pharmaceuticals), BUPROPION HYDROCHLORIDE (RPK Pharmaceuticals), BUPROPION HYDROCHLORIDE (RPK Pharmaceuticals), BUPROPION HYDROCHLORIDE (Radha Pharmaceuticals), BUPROPION HYDROCHLORIDE (Rising Pharma Holdings), BUPROPION HYDROCHLORIDE (SR) (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (SR) (Cipla USA Inc.,), BUPROPION HYDROCHLORIDE (SR) (Dr. Reddy's Laboratories), BUPROPION HYDROCHLORIDE (SR) (Medsource Pharmaceuticals), BUPROPION HYDROCHLORIDE (ScieGen Pharmaceuticals), BUPROPION HYDROCHLORIDE (ScieGen Pharmaceuticals), BUPROPION HYDROCHLORIDE (ScieGen Pharmaceuticals), BUPROPION HYDROCHLORIDE (Slate Run Pharmaceuticals), BUPROPION HYDROCHLORIDE (Slate Run Pharmaceuticals), BUPROPION HYDROCHLORIDE (Sun Pharmaceutical Industries), BUPROPION HYDROCHLORIDE (Sun Pharmaceutical Industries), BUPROPION HYDROCHLORIDE (Sun Pharmaceutical Industries), BUPROPION HYDROCHLORIDE (Sun Pharmaceutical Industries), BUPROPION HYDROCHLORIDE (TWi Pharmaceuticals), BUPROPION HYDROCHLORIDE (TWi Pharmaceuticals), BUPROPION HYDROCHLORIDE (TruPharma LLC), BUPROPION HYDROCHLORIDE (Westminster Pharmaceuticals), BUPROPION HYDROCHLORIDE (Wockhardt USA LLC.), BUPROPION HYDROCHLORIDE (XL) (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (XL) (Chartwell RX), BUPROPION HYDROCHLORIDE (XL) (Lannett Company), BUPROPION HYDROCHLORIDE (XL) (Mullan Phamaceutical), BUPROPION HYDROCHLORIDE (XL) (Proficient Rx LP), BUPROPION HYDROCHLORIDE (XL) (Proficient Rx LP), BUPROPION HYDROCHLORIDE (XL) (Vitruvias Therapeutics), BUPROPION HYDROCHLORIDE (medsource pharmaceuticals), BUPROPION HYDROCHLORIDE SR (DirectRx)
Formula
C13H18ClNO. HCl
Exact mass
275.0844
Mol weight
276.20
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
Remark
ATC code: N06AX12
Chemical structure group: DG00957
Product (DG00957): D00817<US> D07938<US>
Product (mixture): D10751<US> D12493<US>
Efficacy
Antidepressant, Noradrenalin and dopamine reuptake inhibitor
  Disease
Major depressive disorder [DS:H01646]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX12 Bupropion
      D00817  Bupropion hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Bupropion
    D00817  Bupropion hydrochloride (JAN/USP)
 Antidepressants
  Antidepressants, Other
   Bupropion
    D00817  Bupropion hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
   DG00957  Bupropion
    D00817  Bupropion hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00817  Bupropion hydrochloride (JAN/USP) <US>
    SLC6A3 (DAT1)
     D00817  Bupropion hydrochloride (JAN/USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
   DG00957  Bupropion
Other DBs
CAS: 31677-93-7
PubChem: 7847882
ChEBI: 3220
LigandBox: D00817
NIKKAJI: J280.800E
LinkDB
KCF data

ATOM        17
            1   C8y C    15.4700  -16.1700
            2   C5a C    16.7300  -15.4700
            3   C8x C    14.2800  -15.4700
            4   C8x C    15.4700  -17.5700
            5   C1c C    17.9200  -16.1700
            6   O5a O    16.7300  -14.0700
            7   C8y C    13.0900  -16.1700
            8   C8x C    14.2800  -18.2700
            9   N1b N    19.1100  -15.4700
            10  C1a C    17.9200  -17.5700
            11  C8x C    13.0900  -17.5700
            12  X   Cl   11.9000  -15.4700
            13  C1d C    20.3700  -16.1700
            14  C1a C    21.5600  -15.4700
            15  C1a C    20.3700  -17.5700
            16  C1a C    21.5600  -16.9400
            17  X   Cl   25.3400  -15.4700
BOND        16
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 2
            11    7  12 1
            12    9  13 1
            13   13  14 1
            14   13  15 1
            15   13  16 1
            16    8  11 1

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