KEGG   DRUG: Morphine sulfate
Entry
D00842                      Drug                                   

Name
Morphine sulfate (USP);
Morphine sulfate hydrate (JP17);
Morphine sulfate pentahydrate;
Astramor PH (TN);
Avinza (TN);
Depodur (TN);
Kadian (TN);
MS contin (TN)
Product
MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), KADIAN (Actavis Pharma), KADIAN (Allergan), MORPHINE SULFATE (DIRECTRX), MORPHABOND (Daiichi Sankyo), MORPHINE SULFATE (Fresenius Kabi USA), MORPHINE SULFATE (Fresenius Kabi USA), MORPHINE SULFATE (Fresenius Kabi), MORPHINE SULFATE (Hikma Pharmaceuticals USA), DURAMORPH (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lohxa), MORPHINE SULFATE (Meridian Medical Technologies), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (RedPharm Drug), MS CONTIN (Rhodes Pharmaceuticals L.P.), MORPHINE SULFATE (West-Ward Pharmaceuticals Corp), MORPHINE SULFATE (West-Ward Pharmaceuticals Corp.), ARYMO (Zyla Life Sciences US)
  Generic
MORPHINE SULFATE (ANI Pharmaceuticals), MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (American Health Packaging), MORPHINE SULFATE (Amneal Pharmaceuticals of New York LLC), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Civica), MORPHINE SULFATE (Direct_Rx), MORPHINE SULFATE (Hi-Tech Pharmacal), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lupin Pharmaceuticals), MORPHINE SULFATE (Major Pharmaceuticals), MORPHINE SULFATE (Mayne Pharma), MORPHINE SULFATE ORAL SOLUTION CII (Nostrum Laboratories), MORPHINE SULFATE (Novel Laboratories), MORPHINE SULFATE (Pharmaceutical Associates), MITIGO (Piramal Critical Care), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (RedPharm Drug), MORPHINE SULFATE (RedPharm Drug), MORPHINE SULFATE (Rhodes Pharmaceuticals L. P.), MORPHINE SULFATE (Rhodes Pharmaceuticals L.P.), MORPHINE SULFATE (Safecor Health), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (Sun Pharmaceutical Industries), MORPHINE SULFATE (Tris Pharma), MORPHINE SULFATE (Upsher-Smith Laboratories), MORPHINE SULFATE (Upsher-Smith Laboratories), MORPHINE SULFATE (VistaPharm), MORPHINE SULFATE (Zydus Pharmaceuticals (USA)), MORPHINE SULFATE EXTENDED-RELEASE (Sun Pharmaceutical Industries), MORPHINE SULFATE ORAL SOLUTION (Nostrum Laboratories)
Formula
(C17H19NO3)2. H2SO4. 5H2O
Exact mass
758.2932
Mol weight
758.8302
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 8114
ATC code: N02AA01
Chemical structure group: DG00810
Product (DG00810): D00842<JP/US> D02271<JP>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Other map
map05032  Morphine addiction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA01 Morphine
      D00842  Morphine sulfate (USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Morphine
    D00842  Morphine sulfate (USP)
  Opioid Analgesics, Short-acting
   Morphine
    D00842  Morphine sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8114  Morphines
     D00842  Morphine sulfate (USP); Morphine sulfate hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00842  Morphine sulfate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00842  Morphine sulfate hydrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00842
Other DBs
CAS: 6211-15-0
PubChem: 7847907
ChEBI: 50731
ChEMBL: CHEMBL2103744
DrugBank: DB00295
LigandBox: D00842
NIKKAJI: J244.872F
LinkDB
KCF data

ATOM        52
            1   S4a S    29.2515  -20.6431
            2   O1d O    29.2457  -19.2411
            3   O1d O    29.2457  -22.0511
            4   O1d O    27.8437  -20.6374
            5   O1d O    30.6536  -20.6431
            6   O0  O    30.0311  -24.2752
            7   C1z C    18.8784  -23.6206
            8   C8y C    18.8784  -22.2988
            9   C1y C    20.0610  -24.3162
            10  C1y C    17.7653  -24.2467
            11  C1x C    20.0610  -22.9945
            12  C8y C    17.7653  -21.6727
            13  C8y C    20.0610  -21.6727
            14  C1y C    21.1741  -23.6206
            15  C2x C    20.0610  -25.5684
            16  O2x O    16.4436  -22.9248
            17  C1y C    17.7653  -25.5684
            18  C1x C    22.2871  -22.9945
            19  C8y C    17.7653  -20.3509
            20  C1x C    21.1741  -22.3683
            21  C8x C    20.0610  -20.3509
            22  N1y N    22.2871  -24.3162
            23  C2x C    18.8784  -26.2641
            24  O1a O    16.6523  -26.2641
            25  C8x C    18.9480  -19.7249
            26  O1a O    16.6523  -19.7249
            27  C1a C    23.6837  -24.3162
            28  O0  O    30.0311  -24.2752
            29  O0  O    30.0311  -24.2752
            30  O0  O    30.0311  -24.2752
            31  O0  O    30.0311  -24.2752
            32  C1z C    18.8784  -23.6206
            33  C8y C    18.8784  -22.2988
            34  C8y C    17.7653  -21.6727
            35  C8y C    17.7653  -20.3509
            36  C8x C    18.9480  -19.7249
            37  C8x C    20.0610  -20.3509
            38  C8y C    20.0610  -21.6727
            39  C1x C    21.1741  -22.3683
            40  C1y C    21.1741  -23.6206
            41  C1y C    20.0610  -24.3162
            42  C2x C    20.0610  -25.5684
            43  C2x C    18.8784  -26.2641
            44  C1y C    17.7653  -25.5684
            45  C1y C    17.7653  -24.2467
            46  O2x O    16.4436  -22.9248
            47  O1a O    16.6523  -26.2641
            48  N1y N    22.2871  -24.3162
            49  C1x C    22.2871  -22.9945
            50  C1x C    20.0610  -22.9945
            51  C1a C    23.6837  -24.3162
            52  O1a O    16.6523  -19.7249
BOND        54
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     7   8 1
            6     7   9 1
            7     7  10 1
            8     7  11 1 #Up
            9     8  12 2
            10    8  13 1
            11    9  14 1
            12    9  15 1
            13   10  16 1 #Down
            14   10  17 1
            15   11  18 1
            16   12  19 1
            17   13  20 1
            18   13  21 2
            19   14  22 1 #Up
            20   15  23 2
            21   17  24 1 #Down
            22   19  25 2
            23   19  26 1
            24   12  16 1
            25   14  20 1
            26   17  23 1
            27   18  22 1
            28   21  25 1
            29   22  27 1
            30   32  33 1
            31   32  41 1
            32   32  45 1
            33   32  50 1 #Up
            34   33  34 2
            35   33  38 1
            36   41  40 1
            37   41  42 1
            38   45  46 1 #Down
            39   45  44 1
            40   50  49 1
            41   34  35 1
            42   38  39 1
            43   38  37 2
            44   40  48 1 #Up
            45   42  43 2
            46   44  47 1 #Down
            47   35  36 2
            48   35  52 1
            49   34  46 1
            50   40  39 1
            51   44  43 1
            52   49  48 1
            53   37  36 1
            54   48  51 1
BRACKET     1    28.0700  -25.2700   28.0700  -23.2400
            1    30.4500  -23.2400   30.4500  -25.2700
            1  5
 ORIGINAL  1    6
 REPEAT    1   29  30  31  32
            2    14.5600  -27.0200   14.5600  -18.6900
            2    25.4800  -18.6900   25.4800  -27.0200
            2  2
 ORIGINAL  2    7   8  12  19  25  21  13  20  14   9  15  23  17  10  16  24
            2   27  22  18  11  28  26
 REPEAT    2   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            2   49  50  51  52  53  54

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