KEGG   DRUG: Minocycline hydrochloride
Entry
D00850                      Drug                                   

Name
Minocycline hydrochloride (JP17/USP);
Arestin (TN);
Dynacin (TN);
Minocin (TN);
Solodyn (TN)
Product
  Generic
MINOCYCLINE (AvKARE), MINOCYCLINE (Par Pharmaceutical), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (Actavis Pharma), MINOCYCLINE HYDROCHLORIDE (Alvogen), MINOCYCLINE HYDROCHLORIDE (American Health Packaging), MINOCYCLINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York), MINOCYCLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MINOCYCLINE HYDROCHLORIDE (Ascend Laboratories), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (AvKARE), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Cadila Healthcare Limited), MINOCYCLINE HYDROCHLORIDE (Cadila Healthcare Limited), MINOCYCLINE HYDROCHLORIDE (Clinical Solutions Wholesale), MINOCYCLINE HYDROCHLORIDE (DIRECT RX), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Direct Rx), MINOCYCLINE HYDROCHLORIDE (DirectRX), MINOCYCLINE HYDROCHLORIDE (DirectRX), MINOCYCLINE HYDROCHLORIDE (Direct_Rx), MINOCYCLINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), MINOCYCLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MINOCYCLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MINOCYCLINE HYDROCHLORIDE (Lupin Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Major Pharamceuticals), MINOCYCLINE HYDROCHLORIDE (NorthStar Rx LLC), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Oceanside Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Preferred Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (PruGen Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (RPK Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (RPK Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (RedPharm Drug), MINOCYCLINE HYDROCHLORIDE (RedPharm Drug), MINOCYCLINE HYDROCHLORIDE (Sandoz), MINOCYCLINE (Sun Pharmaceutical Industries), MINOCYCLINE HYDROCHLORIDE (Sun Pharmaceutical Industries), MINOCYCLINE HYDROCHLORIDE (Teva Pharmaceuticals USA), MINOCYCLINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), MINOCYCLINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), MINOCYCLINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), MINOCYCLINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C23H27N3O7. HCl
Exact mass
493.1616
Mol weight
493.9373
Structure
Simcomp
Class
Antibacterial
 DG01197  Tetracycline antibiotic
Remark
Therapeutic category: 2760 6152
ATC code: A01AB23 D10AF07 J01AA08
Chemical structure group: DG00009
Product (DG00009): D00850<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Rocky Mountain spotted fever [DS:H00323]
Typhus fever [DS:H00322]
Q fever [DS:H00310]
Lymphogranuloma venereum [DS:H00348]
Psittacosis [DS:H00350]
Trachoma [DS:H00349]
Relapsing fever [DS:H00427]
Chancroid [DS:H00305]
Plague [DS:H00297]
Tularemia [DS:H00312]
Cholera [DS:H00110]
Campylobacter fetus infections [DS:H00321]
Brucellosis [DS:H00325]
Bartonellosis [DS:H00326]
Granuloma inguinale [DS:H01415]
Syphilis [DS:H00354]
Yaws [DS:H01318]
Listeriosis [DS:H00332]
Anthrax [DS:H00328]
Vincent's infection [DS:H01440]
Actinomycosis [DS:H01325]
Acute intestinal amebiasis [DS:H00360]
Acne vulgaris [DS:H01445]
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07019  Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB23 Minocycline
      D00850  Minocycline hydrochloride (JP17/USP) <JP/US>
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF07 Minocycline
      D00850  Minocycline hydrochloride (JP17/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA08 Minocycline
      D00850  Minocycline hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Minocycline
    D00850  Minocycline hydrochloride (JP17/USP)
 Dental and Oral Agents
  Minocycline
   D00850  Minocycline hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  27  Dental preparations
   276  Antibiotics
    2760  Antibiotics
     D00850  Minocycline hydrochloride (JP17/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D00850  Minocycline hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00850  Minocycline hydrochloride
  D00850  Minocycline hydrochloride tablets
  D00850  Minocycline hydrochloride glanules
  D00850  Minocycline hydrochloride for injection
Other DBs
CAS: 13614-98-7
PubChem: 7847915
ChEBI: 50697
ChEMBL: CHEMBL1200881
DrugBank: DB01017
LigandBox: D00850
NIKKAJI: J280.738F
LinkDB
KCF data

ATOM        34
            1   C1y C    26.3399  -16.6515
            2   C1z C    26.3516  -18.0316
            3   C1y C    27.5270  -15.9498
            4   C1x C    25.1294  -15.9791
            5   C2y C    25.1703  -18.7451
            6   C5x C    27.5562  -18.7099
            7   O1a O    26.3516  -19.4294
            8   C2y C    28.7958  -16.6281
            9   N1c N    27.5094  -14.5522
            10  C1y C    23.9423  -16.6866
            11  C2y C    23.9657  -18.0667
            12  O1a O    25.1937  -20.1428
            13  C2y C    28.7433  -18.0082
            14  O5x O    27.5679  -20.1134
            15  O1a O    29.9304  -15.9206
            16  C1a C    28.7141  -13.8388
            17  C1a C    26.2931  -13.8681
            18  C1x C    22.7318  -16.0083
            19  C5x C    22.7727  -18.7861
            20  C5a C    29.9597  -18.6982
            21  C8y C    21.5389  -16.7217
            22  C8y C    21.5621  -18.1135
            23  O5x O    22.7261  -20.1836
            24  N1a N    31.1643  -17.9848
            25  O5a O    29.9772  -20.0960
            26  C8y C    20.3108  -16.0434
            27  C8y C    20.3693  -18.8387
            28  C8x C    19.1179  -16.7685
            29  N1c N    20.2874  -14.6458
            30  C8x C    19.1413  -18.1661
            31  O1a O    20.3985  -20.2422
            32  C1a C    21.4862  -13.9264
            33  C1a C    19.0652  -13.9675
            34  X   Cl   34.4400  -16.8000
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16    9  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   20  24 1
            24   20  25 2
            25   21  26 1
            26   22  27 1
            27   26  28 2
            28   26  29 1
            29   27  30 2
            30   27  31 1
            31   29  32 1
            32   29  33 1
            33    8  13 2
            34   10  11 1
            35   21  22 2
            36   28  30 1

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