KEGG   DRUG: Hydrocortisone sodium phosphate
Entry
D00977                      Drug                                   

Name
Hydrocortisone sodium phosphate (JP17/USP);
Hydrocortone phosphate (TN)
Formula
C21H29O8P. 2Na
Exact mass
486.1395
Mol weight
486.4035
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 2452
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00977  Hydrocortisone sodium phosphate (JP17/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00977  Hydrocortisone sodium phosphate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00977  Hydrocortisone sodium phosphate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00977  Hydrocortisone sodium phosphate (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00977  Hydrocortisone sodium phosphate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00977
Other DBs
CAS: 6000-74-4
PubChem: 7848040
ChEBI: 5781
ChEMBL: CHEMBL1200968
LigandBox: D00977
NIKKAJI: J8.330E
LinkDB
KCF data

ATOM        32
            1   C1z C    13.5800  -13.7200
            2   C1y C    13.5800  -15.0500
            3   C1z C    14.7700  -13.0200
            4   C1x C    12.3900  -13.0200
            5   C1a C    13.5800  -12.3900
            6   C1y C    12.4600  -15.7500
            7   C1x C    15.9600  -15.0500
            8   C1x C    15.9600  -13.7200
            9   C5a C    14.7700  -11.6900
            10  O1a O    16.1000  -12.7400
            11  C1y C    11.2700  -13.7200
            12  C1y C    11.2700  -15.1200
            13  C1x C    12.4600  -17.1500
            14  C1b C    15.9600  -10.9900
            15  O5a O    13.5100  -10.9900
            16  O1a O    10.0100  -13.0200
            17  C1z C    10.0800  -15.7500
            18  C1x C    11.2700  -17.7800
            19  O2b O    17.1500  -11.7600
            20  C2y C    10.0800  -17.1500
            21  C1x C     8.8900  -15.1200
            22  C1a C    10.0100  -14.4900
            23  P1b P    18.4100  -11.0600
            24  C2x C     8.9600  -17.8500
            25  C1x C     7.7000  -15.7500
            26  C5x C     7.7000  -17.2200
            27  O5x O     6.5100  -17.8500
            28  O1c O    18.9700  -12.3200 #-
            29  O1c O    19.6000  -10.2900 #-
            30  O1c O    17.6400   -9.8700
            31  Z   Na   20.7200  -12.3200 #+
            32  Z   Na   21.3500  -10.2900 #+
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   24  26 1
            26   26  27 2
            27    7   8 1
            28   11  12 1
            29   18  20 1
            30   25  26 1
            31   23  28 1
            32   23  29 1
            33   23  30 2

» Japanese version   » Back

DBGET integrated database retrieval system