KEGG   DRUG: Hydrocortisone sodium succinate
Entry
D00978                      Drug                                   

Name
Hydrocortisone sodium succinate (JP17/USP);
A-hydrocort (TN);
Solu-cortef (TN)
Product
Formula
C25H33O8. Na
Exact mass
484.2073
Mol weight
484.5145
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C08178
Therapeutic category: 2452
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Perennial or seasonal allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Nephrotic syndrome [DS:H01657]
Pulmonary tuberculosis [DS:H00342]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis [DS:H01604]
Temporal arteritis [DS:H01698]
Polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00978  Hydrocortisone sodium succinate (JP17/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00978  Hydrocortisone sodium succinate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00978  Hydrocortisone sodium succinate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00978  Hydrocortisone sodium succinate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00978  Hydrocortisone sodium succinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00978
Other DBs
CAS: 125-04-2
PubChem: 7848041
ChEBI: 5782
ChEMBL: CHEMBL1200495
LigandBox: D00978
NIKKAJI: J5.365A
LinkDB
KCF data

ATOM        34
            1   C1z C    20.9235  -16.1233
            2   C1y C    20.9409  -17.4723
            3   C1z C    22.0855  -15.4342
            4   C1x C    19.7729  -15.4518
            5   C1a C    20.9231  -14.8152
            6   C1y C    19.7846  -18.1554
            7   C1x C    23.2184  -17.5247
            8   C1x C    23.2710  -16.0999
            9   C5a C    22.1496  -13.8520
            10  O1a O    23.4403  -15.0020
            11  C1y C    18.5875  -16.1349
            12  C1y C    18.5935  -17.4840
            13  C1x C    19.7846  -19.5044
            14  C1b C    23.3877  -13.1980
            15  O5a O    20.9351  -13.1512
            16  O1a O    17.3613  -15.4401
            17  C1z C    17.4431  -18.1613
            18  C1x C    18.6109  -20.1935
            19  O7a O    24.5848  -13.9512
            20  C2y C    17.4548  -19.5161
            21  C1x C    16.2577  -17.4956
            22  C1a C    17.4310  -16.8708
            23  C7a C    25.7994  -13.2505
            24  C2x C    16.2693  -20.2109
            25  C1x C    15.0839  -18.1730
            26  C1b C    27.0082  -13.9512
            27  O6a O    25.7877  -11.8373
            28  C5x C    15.0605  -19.6037
            29  C1b C    28.2170  -13.2505
            30  O5x O    13.8751  -20.2402
            31  C6a C    29.4141  -13.9512
            32  O6a O    29.4081  -15.3351
            33  O6a O    30.5761  -13.1980 #-
            34  Z   Na   33.3791  -13.5130 #+
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   28  30 2
            30   29  31 1
            31   31  32 2
            32   31  33 1
            33    7   8 1
            34   11  12 1
            35   18  20 1
            36   25  28 1

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