KEGG   DRUG: Triamcinolone hexacetonide
Entry
D00985                      Drug                                   

Name
Triamcinolone hexacetonide (USP/INN);
Aristospan (TN)
Formula
C30H41FO7
Exact mass
532.2836
Mol weight
532.6407
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C08185
ATC code: A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05
Chemical structure group: DG00010
Product (DG00010): D00385<JP> D00983<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Discoid lupus erythematosus [DS:H01595]
Lichen planus [DS:H01654]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC01 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA12 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB09 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB02 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB08 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD11 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA06 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA05 Triamcinolone
      D00985  Triamcinolone hexacetonide (USP/INN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Triamcinolone
   D00985  Triamcinolone hexacetonide (USP/INN)
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Triamcinolone
     D00985  Triamcinolone hexacetonide (USP/INN)
   Glucocorticoids, High Potency
    Triamcinolone
     D00985  Triamcinolone hexacetonide (USP/INN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Triamcinolone
   D00985  Triamcinolone hexacetonide (USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Triamcinolone
    D00985  Triamcinolone hexacetonide (USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Triamcinolone
     D00985  Triamcinolone hexacetonide (USP/INN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Triamcinolone
    D00985  Triamcinolone hexacetonide (USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00985  Triamcinolone hexacetonide (USP/INN)
Other DBs
CAS: 5611-51-8
PubChem: 7848048
ChEBI: 9670
ChEMBL: CHEMBL1200878
DrugBank: DB00620
LigandBox: D00985
NIKKAJI: J8.026H
LinkDB
KCF data

ATOM        38
            1   C2x C    18.6900  -29.1900
            2   C5x C    18.6900  -30.5200
            3   C2x C    19.8800  -31.2200
            4   C2y C    21.0700  -30.5200
            5   C1z C    21.0700  -29.1900
            6   C2x C    19.8800  -28.4900
            7   C1x C    22.2600  -31.2200
            8   C1x C    23.4500  -30.5200
            9   C1y C    23.4500  -29.1900
            10  C1z C    22.2600  -28.4900
            11  C1y C    24.5000  -28.4900
            12  C1z C    24.5000  -27.1600
            13  C1x C    23.4500  -26.4600
            14  C1y C    22.2600  -27.1600
            15  C1x C    26.8800  -28.4900
            16  C1y C    26.8800  -27.1600
            17  C1z C    25.6900  -26.4600
            18  O5x O    17.5700  -31.2200
            19  C1a C    21.0700  -27.7900
            20  X   F    22.2600  -29.8200
            21  O1a O    21.0700  -26.4600
            22  C1a C    24.5000  -25.7600
            23  C5a C    25.6900  -24.8500
            24  O2x O    27.0900  -25.5500
            25  O5a O    26.8800  -24.2200
            26  C1b C    24.5000  -24.2200
            27  O7a O    23.4500  -24.8500
            28  O2x O    28.2800  -27.1600
            29  C1z C    28.4900  -25.5500
            30  C1a C    29.8900  -25.5500
            31  C1a C    28.4900  -24.2200
            32  C7a C    22.2260  -24.1705
            33  C1b C    21.0595  -24.8703
            34  O6a O    22.2716  -22.7512
            35  C1d C    19.8350  -24.1906
            36  C1a C    18.6030  -24.9294
            37  C1a C    19.8116  -22.8200
            38  C1a C    19.8350  -25.5906
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   23  25 2
            29   23  26 1
            30   26  27 1
            31   16  28 1 #Down
            32   24  29 1
            33   29  28 1
            34   29  30 1
            35   29  31 1
            36   27  32 1
            37   32  33 1
            38   32  34 2
            39   33  35 1
            40   35  36 1
            41   35  37 1
            42   35  38 1

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