KEGG   DRUG: Naphazoline nitrateHelp
Entry
D01021                      Drug                                   

Name
Naphazoline nitrate (JP17);
Privine (TN)
Formula
C14H14N2. HNO3
Exact mass
273.1113
Mol weight
273.2872
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Remark
Therapeutic category: 1316 1324
ATC code: R01AA08 R01AB02 S01GA01
Chemical structure group: DG01032
Product (DG01032): D00743<US> D01021<JP>
Efficacy
Vasoconstrictor, alpha1-Adrenergic receptor agonist
Comment
Imidazoline derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07114  Naphthalene family
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA08 Naphazoline
      D01021  Naphazoline nitrate (JP17) <JP>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB02 Naphazoline
      D01021  Naphazoline nitrate (JP17) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA01 Naphazoline
      D01021  Naphazoline nitrate (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1316  Ophthalmic local vasoconstrictors
     D01021  Naphazoline nitrate (JP17)
   132  Otic and nasal agents
    1324  Otolaryngologic vasoconstrictors
     D01021  Naphazoline nitrate (JP17)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Naphazoline
    D01021  Naphazoline nitrate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01021  Naphazoline nitrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01021  Naphazoline nitrate
BRITE hierarchy
Other DBs
CAS: 5144-52-5
PubChem: 7848084
ChEBI: 7471
LigandBox: D01021
NIKKAJI: J300.553D
LinkDB All DBs
KCF data Show

ATOM        20
            1   N2b N    36.3244  -19.0105 #+
            2   O3a O    36.3186  -17.6140
            3   O3a O    37.5567  -19.7146 #-
            4   O1b O    35.1065  -19.7205
            5   C8y C    28.2800  -18.6900
            6   C8y C    29.4700  -17.9900
            7   C8y C    28.2800  -20.0900
            8   C8x C    27.0900  -17.9900
            9   C1b C    29.4700  -16.5900
            10  C8x C    30.8000  -18.6900
            11  C8x C    29.4700  -20.7900
            12  C8x C    27.0900  -20.7900
            13  C8x C    25.8300  -18.6900
            14  C2y C    30.7300  -15.8900
            15  C8x C    30.8000  -20.0900
            16  C8x C    25.8300  -20.0900
            17  N1x N    32.0600  -16.3800
            18  N2x N    30.7300  -14.5600
            19  C1x C    32.9000  -15.1900
            20  C1x C    32.0600  -14.0700
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     5   6 1
            5     5   7 2
            6     5   8 1
            7     6   9 1
            8     6  10 2
            9     7  11 1
            10    7  12 1
            11    8  13 2
            12    9  14 1
            13   10  15 1
            14   12  16 2
            15   14  17 1
            16   14  18 2
            17   17  19 1
            18   18  20 1
            19   11  15 2
            20   13  16 1
            21   19  20 1

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