KEGG   DRUG: Ticlopidine hydrochloride
Entry
D01028                      Drug                                   

Name
Ticlopidine hydrochloride (JP17/USP);
Ticlid (TN)
Formula
C14H14ClNS. HCl
Exact mass
299.0302
Mol weight
300.2466
Structure
Simcomp
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
  DG01808  Thienopyridine
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
   DG01808  Thienopyridine
 DG01809  P2Y12 receptor antagonist
  DG01808  Thienopyridine
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG02892  CYP2B6 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 3399
ATC code: B01AC05
Chemical structure group: DG00156
Product (DG00156): D01028<JP>
Efficacy
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist
  Disease
Thrombotic thrombocytopenic purpura [DS:H00225]
Aplastic anemia [DS:H01132]
Comment
Thienopyridine derivative
Target
P2RY12 [HSA:64805] [KO:K04298]
  Pathway
hsa04611  Platelet activation
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC05 Ticlopidine
      D01028  Ticlopidine hydrochloride (JP17/USP) <JP>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Platelet Modifying Agents
   Adenosine Diphosphate P2Y12
    Ticlopidine
     D01028  Ticlopidine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D01028  Ticlopidine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2RY12
     D01028  Ticlopidine hydrochloride (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01028  Ticlopidine hydrochloride
  D01028  Ticlopidine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01028
Other DBs
CAS: 53885-35-1
PubChem: 7848091
ChEBI: 9589
ChEMBL: CHEMBL1717
DrugBank: DB00208
LigandBox: D01028
NIKKAJI: J281.040I
LinkDB
KCF data

ATOM        18
            1   C8x C    10.2900   -8.6800
            2   C8x C    10.2900  -10.0800
            3   C8x C    11.5024  -10.7800
            4   C8y C    12.7149  -10.0800
            5   C8y C    12.7149   -8.6800
            6   C8x C    11.5024   -7.9800
            7   C1b C    13.9273  -10.7800
            8   N1y N    15.1397  -10.0800
            9   C1x C    15.1397   -8.6800
            10  X   Cl   13.9273   -7.9800
            11  C1x C    16.3522  -10.7800
            12  C8y C    17.5646  -10.0800
            13  C8y C    17.5646   -8.6800
            14  C1x C    16.3522   -7.9800
            15  C8x C    18.8961  -10.5126
            16  C8x C    19.7190   -9.3800
            17  S2x S    18.8961   -8.2474
            18  X   Cl   22.1200   -9.4500
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5  10 1
            11    8  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15    9  14 1
            16   12  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1

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