KEGG   DRUG: Thiethylperazine maleate
Entry
D01130                      Drug                                   
Name
Thiethylperazine maleate (JAN/USP);
Norzine (TN)
Formula
C22H29N3S2. (C4H4O4)2
Exact mass
631.2022
Mol weight
631.7601
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: R06AD03
Chemical structure group: DG01102
Efficacy
Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD03 Thiethylperazine
      D01130  Thiethylperazine maleate (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
     D01130  Thiethylperazine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D01130  Thiethylperazine maleate (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
Other DBs
CAS: 1179-69-7
PubChem: 7848193
ChEBI: 32216
LigandBox: D01130
NIKKAJI: J473.072K
LinkDB
KCF data

ATOM        43
            1   C6a C    40.5832  -20.1140
            2   C2b C    39.9323  -18.9911
            3   O6a O    39.9382  -21.3127
            4   O6a O    41.8853  -20.1079
            5   C2b C    38.2335  -18.9970
            6   C6a C    37.5885  -20.1258
            7   O6a O    36.2863  -20.1258
            8   O6a O    38.2454  -21.2486
            9   C8y C    23.6600  -21.2800
            10  N1y N    24.8500  -20.5100
            11  C8y C    23.6600  -22.6100
            12  C8x C    22.4000  -20.5100
            13  C8y C    26.0400  -21.2800
            14  S2x S    24.8500  -23.3800
            15  C8x C    22.4000  -23.3800
            16  C8x C    21.2100  -21.2800
            17  C8y C    26.0400  -22.6100
            18  C8x C    27.3000  -20.5100
            19  C8x C    21.2100  -22.6100
            20  C8x C    27.3000  -23.3800
            21  C8y C    28.4900  -21.2800
            22  C8x C    28.4900  -22.6100
            23  S2a S    29.6800  -20.5800
            24  C1b C    30.9400  -21.2800
            25  C1a C    32.1300  -20.5800
            26  C1b C    24.8500  -19.1100
            27  C1b C    26.1100  -18.4100
            28  C1b C    27.3000  -19.1100
            29  N1y N    28.4900  -18.4100
            30  C1x C    29.6800  -19.0400
            31  C1x C    30.8700  -18.3400
            32  N1y N    30.8700  -16.9400
            33  C1x C    29.6800  -16.3100
            34  C1x C    28.4900  -17.0100
            35  C1a C    32.1300  -16.2400
            36  C6a C    40.5832  -20.1140
            37  C2b C    39.9323  -18.9911
            38  C2b C    38.2335  -18.9970
            39  C6a C    37.5885  -20.1258
            40  O6a O    36.2863  -20.1258
            41  O6a O    38.2454  -21.2486
            42  O6a O    39.9382  -21.3127
            43  O6a O    41.8853  -20.1079
BOND        44
            1     9  10 1
            2     9  11 2
            3     9  12 1
            4    10  13 1
            5    11  14 1
            6    11  15 1
            7    12  16 2
            8    13  17 2
            9    13  18 1
            10   15  19 2
            11   17  20 1
            12   18  21 2
            13   20  22 2
            14   14  17 1
            15   16  19 1
            16   21  22 1
            17   21  23 1
            18   23  24 1
            19   24  25 1
            20   10  26 1
            21   26  27 1
            22   27  28 1
            23   28  29 1
            24   29  30 1
            25   30  31 1
            26   31  32 1
            27   32  33 1
            28   33  34 1
            29   29  34 1
            30   32  35 1
            31    6   7 1
            32    6   8 2
            33    1   2 1
            34    1   3 1
            35    1   4 2
            36    2   5 2
            37    5   6 1
            38   39  40 1
            39   39  41 2
            40   36  37 1
            41   36  42 1
            42   36  43 2
            43   37  38 2
            44   38  39 1
BRACKET     1    34.5800  -21.9800   34.5800  -18.4100
            1    42.9100  -18.4100   42.9100  -21.9800
            1  2
 ORIGINAL  1    1   2   5   6   7   8   3   4
 REPEAT    1   36  37  38  39  40  41  42  43

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