| Entry |
|
|---|
| Name |
Tazarotene (JAN/USAN/INN);
Avage (TN);
Fabior (TN);
Tazorac (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C21H21NO2S
|
|---|
| Exact mass |
351.1293
|
|---|
| Mol weight |
351.4619
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Product (mixture): | D11932<US> |
|
|---|
| Efficacy |
Anti-acne, Antipsoriatic, Keratolytic, Retinoic acid receptor (RAR) agonist |
|---|
| Disease |
|
|---|
| Comment |
Active form of prodrug: Tazarotenic acid [CPD: C21518]
Carotenoid derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07223 | Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D05 ANTIPSORIATICS
D05A ANTIPSORIATICS FOR TOPICAL USE
D05AX Other antipsoriatics for topical use
D05AX05 Tazarotene
D01132 Tazarotene (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
Dermatological Agents
Acne and Rosacea Agents
Retinoids
Tazarotene
D01132 Tazarotene (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Retinoic acid receptor (RAR)
NR1B (RAR)
D01132 Tazarotene (JAN/USAN/INN) <US>
Hepatocyte nuclear factor 4 like receptors
Retinoid X receptor (RXR)
NR2B2 (RXRB)
D01132 Tazarotene (JAN/USAN/INN) <US>
Prodrugs [br08324.html]
D01132
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 C8y C 26.8694 -16.3717
2 C8x C 28.0726 -17.0781
3 C8x C 29.2881 -16.3833
4 C8y C 29.2941 -14.9831
5 C8x C 28.0845 -14.2777
6 N5x N 26.8689 -14.9727
7 C7a C 30.5096 -14.2881
8 O7a O 31.7192 -14.9934
9 O6a O 30.5157 -12.8879
10 C1b C 32.9349 -14.2984
11 C1a C 34.1445 -15.0038
12 C1x C 18.3938 -18.4674
13 C1x C 18.3938 -19.8676
14 S2x S 19.6093 -20.5677
15 C1z C 19.6093 -17.7673
16 C8y C 20.8177 -18.4674
17 C8y C 20.8116 -19.8676
18 C8x C 22.0212 -20.5728
19 C8x C 23.2369 -19.8780
20 C8y C 23.2428 -18.4778
21 C8x C 22.0332 -17.7724
22 C1a C 20.5930 -16.7702
23 C1a C 18.6059 -16.7702
24 C3b C 24.4584 -17.7830
25 C3b C 25.6634 -17.0742
BOND 27
1 2 3 1
2 3 4 2
3 4 5 1
4 5 6 2
5 6 1 1
6 4 7 1
7 7 8 1
8 7 9 2
9 8 10 1
10 10 11 1
11 13 14 1
12 14 17 1
13 16 15 1
14 15 12 1
15 16 17 2
16 17 18 1
17 18 19 2
18 19 20 1
19 20 21 2
20 21 16 1
21 15 22 1
22 12 13 1
23 15 23 1
24 20 24 1
25 1 2 2
26 24 25 3
27 25 1 1
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