KEGG   DRUG: Tranexamic acid
Entry
D01136                      Drug                                   
Name
Tranexamic acid (JP18/USP/INN);
Cyklokapron (TN);
Rikavarin (TN);
Transamin (TN)
Product
CYKLOKAPRON (Pfizer Laboratories Div Pfizer), TRANEXAMIC ACID IN SODIUM CHLORIDE (Exela Pharma Sciences)
  Generic
TRANEXAMIC ACID (A-S Medication Solutions), TRANEXAMIC ACID (ADVAGEN PHARMA LIMITED), TRANEXAMIC ACID (ANI Pharmaceuticals), TRANEXAMIC ACID (Actavis Pharma), TRANEXAMIC ACID (American Health Packaging), TRANEXAMIC ACID (American Regent), TRANEXAMIC ACID (Amneal Pharmaceuticals LLC), TRANEXAMIC ACID (Amring Pharmaceuticals), TRANEXAMIC ACID (Apotex Corp.), TRANEXAMIC ACID (Armas Pharmaceuticals), TRANEXAMIC ACID (Armas Pharmaceuticals), TRANEXAMIC ACID (Athenex Pharmaceutical Division), TRANEXAMIC ACID (Aurobindo Pharma Limited), TRANEXAMIC ACID (AvPAK), TRANEXAMIC ACID (Avenacy), TRANEXAMIC ACID (Baxter Healthcare Corporation), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Caplin Steriles Limited), TRANEXAMIC ACID (Emcure Pharmaceuticals Limited), TRANEXAMIC ACID (Eugia US LLC), TRANEXAMIC ACID (Fresenius Kabi USA), TRANEXAMIC ACID (Gland Pharma Limited), TRANEXAMIC ACID (HF Acquisition Co LLC), TRANEXAMIC ACID (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), TRANEXAMIC ACID (Heritage Pharmaceuticals Labs Inc. d/b/a Avet Pharmaceuticals Labs), TRANEXAMIC ACID (Heritage Pharmaceuticals Labs Inc. d/b/a Avet Pharmaceuticals Labs), TRANEXAMIC ACID (Methapharm), TRANEXAMIC ACID (Micro Labs Limited), TRANEXAMIC ACID (Mylan Institutional LLC), TRANEXAMIC ACID (Nexus Pharmaceuticals LLC), TRANEXAMIC ACID (Northstar Rx LLC), TRANEXAMIC ACID (Proficient Rx LP), TRANEXAMIC ACID (Provepharm), TRANEXAMIC ACID (REMEDYREPACK), TRANEXAMIC ACID (Sagent Pharmaceuticals), TRANEXAMIC ACID (Sagent Pharmaceuticals), TRANEXAMIC ACID (XGen Pharmaceuticals DJB), TRANEXAMIC ACID (Zydus Lifesciences Limited), TRANEXAMIC ACID (Zydus Pharmaceuticals (USA)), TRANEXAMIC ACID IN SODIUM CHLORIDE (Amneal Pharmaceuticals Private Limited), TRANEXAMIC ACID IN SODIUM CHLORIDE (Fresenius Kabi USA), TRANEXAMIC ACID IN SODIUM CHLORIDE (Gland Pharma Limited), TRANEXAMIC ACID IN SODIUM CHLORIDE (HP Halden Pharma AS)
Formula
C8H15NO2
Exact mass
157.1103
Mol weight
157.21
Structure
Simcomp
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02012  Antifibrinolytic
   DG01540  Plasmin inhibitor
Remark
Same as: C12535
Therapeutic category: 3327 4490
ATC code: B02AA02
Product: D01136<JP/US>
Efficacy
Antifibrinolytic, Anti-inflammatory, Plasmin inhibitor
  Disease
Hemophilia [DS:H00219]
Target
Plasmin [CPD:C00471] [HSA:5340] [KO:K01315]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06513  Complement cascade
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02A ANTIFIBRINOLYTICS
    B02AA Amino acids
     B02AA02 Tranexamic acid
      D01136  Tranexamic acid (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Hemostasis Agents
   Tranexamic Acid
    D01136  Tranexamic acid (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   332  Hemostatics
    3327  Antiplasmins
     D01136  Tranexamic acid (JP18/USP/INN)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01136  Tranexamic acid (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Nourishing tonics and health supplements
  38 Vitamin C based drugs
   D01136  Tranexamic acid (JP18/USP/INN)
 Agents for dental and stomatological use
  73 Stomatologic and laryngologic remedies (incl. toche without claims for cough and phlegm)
   D01136  Tranexamic acid (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Tranexamic acid
    D01136  Tranexamic acid (JP18/USP/INN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Tranexamic acid
    D01136  Tranexamic acid (JP18/USP/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02012  Antifibrinolytic
    DG01540  Plasmin inhibitor
     D01136  Tranexamic acid
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    Plasmin
     D01136  Tranexamic acid (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01136  Tranexamic acid
  D01136  Tranexamic acid tablets
  D01136  Tranexamic acid capsules
  D01136  Tranexamic acid injection
Rx-to-OTC switch list in Japan [br08314.html]
 D01136
Other DBs
CAS: 1197-18-8
PubChem: 7848199
ChEBI: 48669
PDB-CCD: AMH[PDBj]
LigandBox: D01136
NIKKAJI: J3.664A
LinkDB
KCF data

ATOM        11
            1   C1x C    23.7617  -17.2548
            2   C1x C    23.7617  -18.6550
            3   C1y C    24.9772  -19.3552
            4   C1x C    26.1856  -18.6550
            5   C1x C    26.1856  -17.2548
            6   C1y C    24.9772  -16.5547
            7   C6a C    24.9789  -15.1545
            8   O6a O    26.1924  -14.4560
            9   O6a O    23.7673  -14.4529
            10  C1b C    24.9789  -20.7554
            11  N1a N    26.1924  -21.4540
BOND        11
            1     5   6 1
            2     6   1 1
            3     6   7 1
            4     1   2 1
            5     7   8 1
            6     2   3 1
            7     7   9 2
            8     3   4 1
            9     3  10 1 #Down
            10    4   5 1
            11   10  11 1

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