KEGG   DRUG: Acetazolamide sodium
Entry
D01196                      Drug                                   

Name
Acetazolamide sodium (JAN);
Diamox (TN)
Product
  Generic
Formula
C4H5N4O3S2. Na
Exact mass
243.9701
Mol weight
244.2273
Structure
Simcomp
Class
Cardiovascular agent
 DG01534  Carbonic anhydrase inhibitor
Remark
Therapeutic category: 2134
ATC code: S01EC01
Chemical structure group: DG01134
Product (DG01134): D00218<JP/US> D01196<JP/US>
Efficacy
Antiglaucoma, Carbonic anhydrase inhibitor
  Disease
Chronic simple (open-angle) glaucoma [DS:H00612]
Comment
Sulfonamide derivative
Diuretic action
Target
  Pathway
hsa04964  Proximal tubule bicarbonate reclamation
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07033  Anticonvulsants
map07054  Antiglaucoma agents
map07055  Sulfonamide derivatives - overview
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC01 Acetazolamide
      D01196  Acetazolamide sodium (JAN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Other
   Acetazolamide
    D01196  Acetazolamide sodium (JAN)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Carbonic Anhydrase Inhibitors, Ophthalmic
    Acetazolamide
     D01196  Acetazolamide sodium (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2134  Carbonic anhydrase inhibitors
     D01196  Acetazolamide sodium (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA
     D01196  Acetazolamide sodium (JAN) <JP/US>
Other DBs
CAS: 1424-27-7
PubChem: 7848259
ChEBI: 31163
ChEMBL: CHEMBL1200814
DrugBank: DB00819
LigandBox: D01196
NIKKAJI: J24.636K
LinkDB
KCF data

ATOM        14
            1   N5x N    25.5209  -16.3791
            2   C8y C    25.9582  -15.0505
            3   S2x S    24.8212  -14.2224
            4   C8y C    23.6844  -15.0505
            5   N5x N    24.1217  -16.3791
            6   N1b N    27.1654  -14.3451
            7   C5a C    28.3702  -15.0373
            8   C1a C    29.5819  -14.3378
            9   O5a O    28.3733  -16.4368
            10  S4a S    22.2790  -15.0465
            11  O3c O    22.2790  -13.6470
            12  O3c O    20.8795  -15.0465
            13  N1a N    22.2790  -16.4461 #-
            14  Z   Na   19.6199  -17.1459 #+
BOND        13
            1     6   7 1
            2     1   2 2
            3     7   8 1
            4     2   3 1
            5     7   9 2
            6     3   4 1
            7     4   5 2
            8     5   1 1
            9     2   6 1
            10    4  10 1
            11   10  11 2
            12   10  12 2
            13   10  13 1

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