KEGG   DRUG: Warfarin potassium
Entry
D01280                      Drug                                   

Name
Warfarin potassium (JP17);
Athrombin-K (TN)
Formula
C19H15O4. K
Exact mass
346.0607
Mol weight
346.4183
Structure
Simcomp
Class
Cardiovascular agent
 DG01708  Coumarin anticoagulant
  DG01760  Warfarin and analog
 DG01950  Antithrombotic agent
  DG01708  Coumarin anticoagulant
   DG01760  Warfarin and analog
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 3332
ATC code: B01AA03
Chemical structure group: DG00149
Product (DG00149): D00564<US> D01280<JP>
Efficacy
Anticoagulant, Vitamin K antagonist
Comment
coumarin derivative
Target
VKORC1 [HSA:79001] [KO:K05357]
NQO1 [HSA:1728] [KO:K00355]
  Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AA Vitamin K antagonists
     B01AA03 Warfarin
      D01280  Warfarin potassium (JP17) <JP>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Vitamin K Antagonist
    Warfarin
     D01280  Warfarin potassium (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3332  Dicumarols
     D01280  Warfarin potassium (JP17)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   NAD(P)H dehydrogenase
    NQO1
     D01280  Warfarin potassium (JP17) <JP>
   Vitamin-K-epoxide reductase
    VKORC1
     D01280  Warfarin potassium (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01280  Warfarin potassium
  D01280  Warfarin potassium tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01280
Other DBs
CAS: 2610-86-8
PubChem: 7848343
ChEBI: 32301
ChEMBL: CHEMBL1200772
DrugBank: DB00682
LigandBox: D01280
NIKKAJI: J7.630I
LinkDB
KCF data

ATOM        24
            1   C8y C    24.8561  -17.2746
            2   C1c C    26.0688  -17.9857
            3   C8y C    23.6435  -17.9683
            4   C8y C    24.8620  -15.8811
            5   C1b C    27.2872  -17.2862
            6   C8y C    22.4425  -17.2570
            7   O1a O    23.6376  -19.3675 #-
            8   O7x O    23.6609  -15.1815
            9   O6a O    26.0862  -15.1932
            10  C5a C    28.4940  -17.9973
            11  C8y C    22.4484  -15.8637
            12  C8x C    21.2299  -17.9683
            13  C1a C    28.4881  -19.4025
            14  O5a O    29.7066  -17.3037
            15  C8x C    21.2357  -15.1641
            16  C8x C    20.0231  -17.2629
            17  C8x C    20.0231  -15.8578
            18  C8y C    26.0624  -19.3898
            19  C8x C    24.8299  -20.0941
            20  C8x C    24.8237  -21.4941
            21  C8x C    26.0330  -22.1995
            22  C8x C    27.2655  -21.4952
            23  C8x C    27.2717  -20.0952
            24  Z   K    21.3765  -19.4017 #+
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 2
            14   11  15 1
            15   12  16 2
            16   15  17 2
            17    8  11 1
            18   16  17 1
            19    2  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1

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