KEGG   DRUG: Midodrine hydrochloride
Entry
D01307                      Drug                                   

Name
Midodrine hydrochloride (JAN/USP);
Pro-Amatine (TN)
Product
  Generic
MIDODRINE HYDROCHLORIDE (Alembic Pharmaceuticals), MIDODRINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), MIDODRINE HYDROCHLORIDE (American Health Packaging), MIDODRINE HYDROCHLORIDE (Apotex Corp), MIDODRINE HYDROCHLORIDE (Aurobindo Pharma Limited), MIDODRINE HYDROCHLORIDE (AvKARE), MIDODRINE HYDROCHLORIDE (AvPAK), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Bryant Ranch Prepack), MIDODRINE HYDROCHLORIDE (Cadila Healthcare Limited), MIDODRINE HCL (Cardinal Health), MIDODRINE HYDROCHLORIDE (Cardinal Health), MIDODRINE HYDROCHLORIDE (Cardinal Health), MIDODRINE HYDROCHLORIDE (Drug Ocean LLC), MIDODRINE HCL (Eon Labs), MIDODRINE HYDROCHLORIDE (Golden State Medical Supply), MIDODRINE HYDROCHLORIDE (Major Pharmaceuticals), MIDODRINE HYDROCHLORIDE (Mylan Institutional), MIDODRINE HYDROCHLORIDE (Mylan Pharmaceuticals), MIDODRINE HYDROCHLORIDE (NCS HealthCare of KY), MIDODRINE HYDROCHLORIDE (NCS HealthCare of KY), MIDODRINE HYDROCHLORIDE (Par Pharmaceutical), MIDODRINE HYDROCHLORIDE (Proficient Rx LP), MIDODRINE HYDROCHLORIDE (Rising Pharmaceuticals), MIDODRINE HYDROCHLORIDE (TruPharma), MIDODRINE HYDROCHLORIDE (Upsher-Smith laboratories), MIDODRINE HYDROCHLORIDE (Xiromed), MIDODRINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C12H18N2O4. HCl
Exact mass
290.1033
Mol weight
290.7433
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 2160
ATC code: C01CA17
Chemical structure group: DG00224
Product (DG00224): D01307<JP/US>
Efficacy
Antihypotensive, alpha1-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Active form of prodrug: Deglymidodrine [CPD:C21521]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA17 Midodrine
      D01307  Midodrine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Midodrine
    D01307  Midodrine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D01307  Midodrine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01307  Midodrine hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01307
Prodrugs [br08324.html]
 DG00224
Other DBs
CAS: 3092-17-9
PubChem: 7848370
ChEBI: 31847
ChEMBL: CHEMBL1200461
DrugBank: DB00211
LigandBox: D01307
LinkDB
KCF data

ATOM        19
            1   X   Cl   27.9649  -19.4803
            2   C8y C    17.4300  -16.0300
            3   C8x C    17.4300  -17.4300
            4   C8x C    18.6200  -18.1300
            5   C8y C    19.8800  -17.4300
            6   C8y C    19.8800  -16.0300
            7   C8x C    18.6200  -15.3300
            8   C1c C    21.0700  -15.3300
            9   C1b C    22.2600  -16.0300
            10  O1a O    21.0700  -13.9300
            11  N1b N    23.4500  -15.3300
            12  C5a C    24.7100  -16.0300
            13  C1b C    25.9000  -15.3300
            14  N1a N    27.0900  -16.0300
            15  O5a O    24.7100  -17.4300
            16  O2a O    16.1700  -15.3300
            17  C1a C    14.9800  -16.0300
            18  O2a O    21.0700  -18.1300
            19  C1a C    21.0700  -19.5300
BOND        18
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     8  10 1
            10    9  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   12  15 2
            15    2  16 1
            16   16  17 1
            17    5  18 1
            18   18  19 1

» Japanese version   » Back

DBGET integrated database retrieval system