KEGG   DRUG: Midodrine hydrochloride
Entry
D01307                      Drug                                   

Name
Midodrine hydrochloride (JAN/USP);
Pro-Amatine (TN)
Product
  Generic
Formula
C12H18N2O4. HCl
Exact mass
290.1033
Mol weight
290.7433
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 2160
ATC code: C01CA17
Chemical structure group: DG00224
Product (DG00224): D01307<JP/US>
Efficacy
Antihypotensive, alpha1-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Active form of prodrug: Deglymidodrine [CPD:C21521]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA17 Midodrine
      D01307  Midodrine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Midodrine
    D01307  Midodrine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D01307  Midodrine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01307  Midodrine hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01307
Prodrugs [br08324.html]
 DG00224
Other DBs
CAS: 3092-17-9
PubChem: 7848370
ChEBI: 31847
ChEMBL: CHEMBL1200461
DrugBank: DB00211
LigandBox: D01307
LinkDB
KCF data

ATOM        19
            1   X   Cl   27.9649  -19.4803
            2   C8y C    17.4300  -16.0300
            3   C8x C    17.4300  -17.4300
            4   C8x C    18.6200  -18.1300
            5   C8y C    19.8800  -17.4300
            6   C8y C    19.8800  -16.0300
            7   C8x C    18.6200  -15.3300
            8   C1c C    21.0700  -15.3300
            9   C1b C    22.2600  -16.0300
            10  O1a O    21.0700  -13.9300
            11  N1b N    23.4500  -15.3300
            12  C5a C    24.7100  -16.0300
            13  C1b C    25.9000  -15.3300
            14  N1a N    27.0900  -16.0300
            15  O5a O    24.7100  -17.4300
            16  O2a O    16.1700  -15.3300
            17  C1a C    14.9800  -16.0300
            18  O2a O    21.0700  -18.1300
            19  C1a C    21.0700  -19.5300
BOND        18
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     8  10 1
            10    9  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   12  15 2
            15    2  16 1
            16   16  17 1
            17    5  18 1
            18   18  19 1

» Japanese version   » Back

DBGET integrated database retrieval system