KEGG   DRUG: Epoprostenol sodium
Entry
D01337                      Drug                                   

Name
Epoprostenol sodium (JAN/USAN);
Flolan (TN);
Veletri (TN)
Product
  Generic
Formula
C20H31O5. Na
Exact mass
374.2069
Mol weight
374.4469
Structure
Simcomp
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
 DG01810  Prostacycline derivative
Other
 DG01961  Prostaglandin derivative
  DG01810  Prostacycline derivative
 DG02573  Prostanoid derivative
  DG01961  Prostaglandin derivative
   DG01810  Prostacycline derivative
Remark
Therapeutic category: 2190
ATC code: B01AC09
Chemical structure group: DG00157
Product (DG00157): D01337<JP/US>
Efficacy
Antihypertensive, Platelet aggregation inhibitor, Prostaglandin I2 receptor agonist
  Disease
Pulmonary arterial hypertension [DS:H01621]
Comment
Prostacycline derivative
Target
PTGIR [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
Interaction
Structure map
map07034  Eicosanoids
map07049  Antithrombosis agents
map07228  Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC09 Epoprostenol
      D01337  Epoprostenol sodium (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Prostacyclin Vasodilators
    Epoprostenol
     D01337  Epoprostenol sodium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D01337  Epoprostenol sodium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    PTGIR
     D01337  Epoprostenol sodium (JAN/USAN) <JP/US>
Other DBs
CAS: 61849-14-7
PubChem: 7848400
ChEBI: 31548
ChEMBL: CHEMBL962
DrugBank: DB01240
LigandBox: D01337
NIKKAJI: J18.157I
LinkDB
KCF data

ATOM        26
            1   Z   Na   26.1044  -10.2395 #+
            2   C1y C    25.1300  -19.0400
            3   C1y C    23.8000  -18.6200
            4   C1y C    25.1300  -20.4400
            5   C1x C    25.8300  -17.7800
            6   O2x O    23.8000  -17.1500
            7   C1x C    23.0300  -19.7400
            8   C1y C    23.8700  -20.8600
            9   C2b C    26.3200  -21.1400
            10  C2y C    25.1300  -16.5200
            11  O1a O    23.3800  -22.1900
            12  C2b C    27.5100  -20.4400
            13  C2b C    26.3200  -15.8200
            14  C1c C    28.7000  -21.1400
            15  C1b C    29.9600  -20.4400
            16  O1a O    28.7000  -22.4700
            17  C1b C    31.1500  -21.1400
            18  C1b C    32.3400  -20.4400
            19  C1b C    33.5300  -21.1400
            20  C1a C    34.7200  -20.4400
            21  C1b C    26.3900  -14.4200
            22  C1b C    27.5800  -13.7200
            23  C1b C    27.5800  -12.3200
            24  C6a C    28.7700  -11.6200
            25  O6a O    30.0300  -12.3200
            26  O6a O    28.7700  -10.2200 #-
BOND        26
            1     2   3 1
            2     2   4 1
            3     2   5 1 #Down
            4     3   6 1 #Down
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Up
            8     5  10 1
            9     8  11 1 #Down
            10    9  12 2
            11   10  13 2
            12   12  14 1
            13   14  15 1
            14   14  16 1 #Down
            15   15  17 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19    6  10 1
            20    7   8 1
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 2
            26   24  26 1

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