KEGG   DRUG: Betamethasone valerate
Entry
D01357                      Drug                                   

Name
Betamethasone valerate (JP17/USP);
Beta-Val (TN);
Luxiq (TN);
Rinderon-V (TN)
Product
  Generic
Formula
C27H37FO6
Exact mass
476.2574
Mol weight
476.5775
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Product (mixture): D04773<JP> D04796<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D01357  Betamethasone valerate (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Betamethasone
     D01357  Betamethasone valerate (JP17/USP)
   Glucocorticoids, High Potency
    Betamethasone
     D01357  Betamethasone valerate (JP17/USP)
   Glucocorticoids, Very High Potency
    Betamethasone
     D01357  Betamethasone valerate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01357  Betamethasone valerate (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D01357  Betamethasone valerate (JP17/USP)
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01357  Betamethasone valerate (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Betamethasone valerate
    D01357  Betamethasone valerate (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Betamethasone valerate
    D01357  Betamethasone valerate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01357  Betamethasone valerate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01357  Betamethasone valerate
Topical steroids potency [br08317.html]
 Classification in Japan
  D01357
Other DBs
CAS: 2152-44-5
PubChem: 7848420
ChEBI: 31277
ChEMBL: CHEMBL1497
DrugBank: DB00443
LigandBox: D01357
NIKKAJI: J7.337G
LinkDB
KCF data

ATOM        34
            1   C2x C     5.4764  -10.5555
            2   C5x C     5.4764  -11.9007
            3   C2x C     6.6413  -12.5733
            4   C2y C     7.8063  -11.9007
            5   C1z C     7.8063  -10.5555
            6   C2x C     6.6413   -9.8830
            7   C1x C     8.9713  -12.5733
            8   C1x C    10.1362  -11.9007
            9   C1y C    10.1362  -10.5555
            10  C1z C     8.9713   -9.8830
            11  C1y C    11.3011   -9.8830
            12  C1z C    11.3011   -8.5378
            13  C1x C    10.1362   -7.8652
            14  C1y C     8.9713   -8.5378
            15  C1x C    13.6310   -9.8830
            16  C1y C    13.6310   -8.5378
            17  C1z C    12.4661   -7.8652
            18  C1a C     7.8063   -9.2103
            19  O1a O     7.8083   -7.8664
            20  C1a C    11.3011   -7.1927
            21  C1a C    14.7836   -7.8722
            22  C5a C    12.4661   -6.1138
            23  X   F     8.9713  -11.2281
            24  O7a O    14.2538   -6.7775
            25  O5x O     4.3116  -12.5733
            26  O5a O    13.6350   -5.4390
            27  C1b C    11.3050   -5.4434
            28  C7a C    15.6379   -6.7775
            29  O6a O    16.3156   -7.9508
            30  C1b C    16.3407   -5.5606
            31  C1b C    17.7063   -5.5610
            32  O1a O    10.0592   -6.1628
            33  C1b C    18.4212   -4.3241
            34  C1a C    19.8099   -4.3249
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Up
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   24  28 1
            32   28  29 2
            33   28  30 1
            34   30  31 1
            35   27  32 1
            36   31  33 1
            37   33  34 1

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