KEGG   DRUG: Ephedrine hydrochloride
Entry
D01386                      Drug                                   

Name
Ephedrine hydrochloride (JP17/USP);
Ephedrine hydrochloride (TN)
Formula
C10H15NO. HCl
Exact mass
201.092
Mol weight
201.6931
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Remark
Therapeutic category: 2118 2221
ATC code: C01CA26 R01AA03 R01AB05 R03CA02 S01FB02
Chemical structure group: DG00227
Product (DG00227): D01386<JP> D04018<US>
Product (mixture): D04299<JP> D04307<JP> D04338<JP>
Efficacy
Antitussive, Bronchodilator, Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D01386  Ephedrine hydrochloride (JP17/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2118  Alkaloids
     D01386  Ephedrine hydrochloride (JP17/USP)
  22  Respiratory organ agents
   222  Antitussives
    2221  Ephedrines and Ephedra herbs
     D01386  Ephedrine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ephedrine
    D01386  Ephedrine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01386  Ephedrine hydrochloride (JP17/USP) <JP>
    ADRA2
     D01386  Ephedrine hydrochloride (JP17/USP) <JP>
    ADRB
     D01386  Ephedrine hydrochloride (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01386  Ephedrine hydrochloride
  D01386  Ephedrine hydrochloride tablets
  D01386  10% Ephedrine hydrochloride powder
  D01386  Ephedrine hydrochloride injection
Rx-to-OTC switch list in the USA [br08315.html]
 D01386
Other DBs
CAS: 50-98-6
PubChem: 7848449
ChEBI: 31541
ChEMBL: CHEMBL2146102
LigandBox: D01386
NIKKAJI: J231.451G
LinkDB
KCF data

ATOM        13
            1   C8x C    17.0325  -17.0009
            2   C8x C    17.0325  -18.4031
            3   C8x C    18.2497  -19.1041
            4   C8x C    19.4598  -18.4031
            5   C8y C    19.4598  -17.0009
            6   C8x C    18.2497  -16.2999
            7   C1c C    20.6653  -16.2999
            8   C1c C    21.8762  -16.9938
            9   N1b N    23.0872  -16.2927
            10  C1a C    24.2981  -16.9867
            11  O1a O    20.6609  -14.8977
            12  C1a C    21.8793  -18.3959
            13  X   Cl   29.1200  -17.5000
BOND        12
            1     6   1 1
            2     5   7 1
            3     1   2 2
            4     7   8 1
            5     2   3 1
            6     8   9 1
            7     3   4 2
            8     9  10 1
            9     4   5 1
            10    7  11 1 #Up
            11    5   6 2
            12    8  12 1 #Up

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