KEGG   DRUG: Benzydamine hydrochloride
Entry
D01410                      Drug                                   

Name
Benzydamine hydrochloride (JAN/USAN);
Tantum (TN)
Formula
C19H23N3O. HCl
Exact mass
345.1608
Mol weight
345.8664
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
Remark
ATC code: A01AD02 G02CC03 M01AX07 M02AA05 R02AX03
Chemical structure group: DG00014
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Benzimidazole derivative
nonsteroidal antiinflammatory drug (NSAIDs), basic
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
ALOX5 [HSA:240] [KO:K00461]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD02 Benzydamine (except lozenges)
      D01410  Benzydamine hydrochloride (JAN/USAN)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC03 Benzydamine
      D01410  Benzydamine hydrochloride (JAN/USAN)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX07 Benzydamine
      D01410  Benzydamine hydrochloride (JAN/USAN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA05 Benzydamine
      D01410  Benzydamine hydrochloride (JAN/USAN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX03 Benzydamine (only lozenges)
      D01410  Benzydamine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dioxygenases
    ALOX5
     D01410  Benzydamine hydrochloride (JAN/USAN)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01410  Benzydamine hydrochloride (JAN/USAN)
    PTGS2 (COX2)
     D01410  Benzydamine hydrochloride (JAN/USAN)
Other DBs
CAS: 132-69-4
PubChem: 7848473
ChEBI: 31266
ChEMBL: CHEMBL1528134
LigandBox: D01410
NIKKAJI: J363.278D
LinkDB
KCF data

ATOM        24
            1   X   Cl   33.1118  -17.5903
            2   C8x C    22.8597  -19.7214
            3   C8x C    21.6482  -19.0196
            4   C8x C    21.6482  -17.6158
            5   C8x C    22.8597  -16.9140
            6   C8y C    24.0784  -19.0196
            7   C8y C    24.0816  -17.6153
            8   N4y N    25.4181  -17.1845
            9   N5x N    26.2406  -18.3225
            10  C8y C    25.4129  -19.4565
            11  C1b C    26.2421  -16.0479
            12  C8y C    27.6457  -16.0479
            13  C8x C    28.3477  -17.2632
            14  C8x C    29.7513  -17.2632
            15  C8x C    30.4530  -16.0475
            16  C8x C    29.7511  -14.8321
            17  C8x C    28.3474  -14.8321
            18  O2a O    25.4129  -20.8603
            19  C1b C    26.6181  -21.5561
            20  C1b C    27.8273  -20.8578
            21  C1b C    29.0128  -21.5421
            22  N1c N    30.2098  -20.8507
            23  C1a C    31.4013  -21.5385
            24  C1a C    30.2097  -19.4387
BOND        25
            1     6   2 1
            2     2   3 2
            3    11   8 1
            4     3   4 1
            5     4   5 2
            6     6   7 2
            7    11  12 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11   10   6 1
            12    5   7 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  12 1
            19   10  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   22  24 1

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