KEGG   DRUG: Flumethasone pivalate
Entry
D01464                      Drug                                   

Name
Flumethasone pivalate (USP);
Flumetasone pivalate (JAN/BAN);
Locorten (TN)
Formula
C27H36F2O6
Exact mass
494.248
Mol weight
494.5679
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: D07AB03 D07XB01
Chemical structure group: DG00412
Efficacy
Anti-inflammaotry, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB03 Flumetasone
      D01464  Flumethasone pivalate (USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB01 Flumetasone
      D01464  Flumethasone pivalate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01464  Flumethasone pivalate (USP)
Other DBs
CAS: 2002-29-1
PubChem: 7848527
ChEBI: 31620
ChEMBL: CHEMBL1200877 CHEMBL2359842 CHEMBL3039447
DrugBank: DB00663
LigandBox: D01464
NIKKAJI: J7.845J
LinkDB
KCF data

ATOM        35
            1   C2x C    19.6000  -28.5600
            2   C5x C    19.6000  -29.9600
            3   C2x C    20.8600  -30.5900
            4   C2y C    22.0500  -29.9600
            5   C1z C    22.0500  -28.5600
            6   C2x C    20.8600  -27.9300
            7   C1y C    23.1700  -30.5900
            8   C1x C    24.3600  -29.9600
            9   C1y C    24.3600  -28.5600
            10  C1z C    23.1700  -27.9300
            11  C1y C    25.5500  -27.9300
            12  C1z C    25.5500  -26.5300
            13  C1x C    24.3600  -25.9000
            14  C1y C    23.1700  -26.5300
            15  C1x C    27.9300  -27.9300
            16  C1y C    27.9300  -26.5300
            17  C1z C    26.7400  -25.9000
            18  C1a C    22.0500  -27.2300
            19  O1a O    22.0500  -25.9000
            20  C1a C    25.5500  -25.2000
            21  C1a C    29.0500  -25.9000
            22  C5a C    26.7400  -24.1500
            23  X   F    23.1700  -29.2600
            24  O1a O    27.9300  -24.9900
            25  O5x O    18.4100  -30.5900
            26  O5a O    27.9300  -23.5200
            27  X   F    23.1000  -31.9900
            28  C1b C    25.5406  -23.4279
            29  O7a O    24.3135  -24.1066
            30  C7a C    23.0850  -23.3672
            31  C1d C    21.8663  -24.0417
            32  O6a O    23.1104  -21.9800
            33  C1a C    20.6333  -23.3002
            34  C1a C    23.0787  -24.7417
            35  C1a C    20.6538  -24.7417
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30    7  27 1 #Down
            31   22  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   30  32 2
            36   31  33 1
            37   31  34 1
            38   31  35 1

» Japanese version   » Back

DBGET integrated database retrieval system