KEGG   DRUG: Etilefrine hydrochloride
Entry
D01573                      Drug                                   

Name
Etilefrine hydrochloride (JP17);
Etilefrine hydrochloride (TN)
Formula
C10H15NO2. HCl
Exact mass
217.087
Mol weight
217.6925
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Remark
Therapeutic category: 2119
ATC code: C01CA01
Chemical structure group: DG00210
Product (DG00210): D01573<JP>
Efficacy
Antihypotensive, Cardiotonic, Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA01 Etilefrine
      D01573  Etilefrine hydrochloride (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D01573  Etilefrine hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01573  Etilefrine hydrochloride (JP17) <JP>
    ADRA2
     D01573  Etilefrine hydrochloride (JP17) <JP>
    ADRB
     D01573  Etilefrine hydrochloride (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01573  Etilefrine hydrochloride
  D01573  Etilefrine hydrochloride tablets
Other DBs
CAS: 943-17-9
PubChem: 7848636
ChEBI: 31582
ChEMBL: CHEMBL3187408
LigandBox: D01573
NIKKAJI: J237.911B
LinkDB
KCF data

ATOM        14
            1   C8y C    27.7200  -15.6100
            2   C8x C    27.7200  -17.0100
            3   C8x C    28.9100  -17.7100
            4   C8x C    30.1000  -17.0100
            5   C8y C    30.1000  -15.6100
            6   C8x C    28.9100  -14.9100
            7   C1c C    31.2900  -14.9100
            8   C1b C    32.5500  -15.6100
            9   N1b N    33.7400  -14.9100
            10  C1b C    34.9300  -15.6100
            11  C1a C    36.1900  -14.9100
            12  O1a O    31.2900  -13.5100
            13  O1a O    26.4600  -14.9100
            14  X   Cl   34.7900  -17.0800
BOND        13
            1     5   7 1
            2     7   8 1
            3     1   2 2
            4     8   9 1
            5     2   3 1
            6     9  10 1
            7     3   4 2
            8    10  11 1
            9     4   5 1
            10    7  12 1
            11    5   6 2
            12    1  13 1
            13    6   1 1

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