KEGG   DRUG: Pranoprofen
Entry
D01578                      Drug                                   

Name
Pranoprofen (JP17/INN);
Elicapric (TN)
Formula
C15H13NO3
Exact mass
255.0895
Mol weight
255.2686
Structure
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
Therapeutic category: 1149 1319
ATC code: S01BC09
Product: D01578<JP>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC09 Pranoprofen
      D01578  Pranoprofen (JP17/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01578  Pranoprofen (JP17/INN)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01578  Pranoprofen (JP17/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  62 General eye drops
   D01578  Pranoprofen (JP17/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Pranoprofen
    D01578  Pranoprofen (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01578  Pranoprofen (JP17/INN) <JP>
    PTGS2 (COX2)
     D01578  Pranoprofen (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01578  Pranoprofen
Rx-to-OTC switch list in Japan [br08314.html]
 D01578
Other DBs
CAS: 52549-17-4
PubChem: 7848641
ChEBI: 32040
ChEMBL: CHEMBL367463
LigandBox: D01578
NIKKAJI: J9.293B
LinkDB
KCF data

ATOM        19
            1   C8x C    23.5900  -26.2500
            2   C8x C    23.5900  -24.8500
            3   C8x C    24.7800  -24.1500
            4   N5x N    24.7800  -26.9500
            5   C8y C    25.9700  -26.2500
            6   C8y C    25.9700  -24.8500
            7   C1x C    27.2300  -24.1500
            8   O2x O    27.2300  -26.9500
            9   C8y C    28.4200  -26.2500
            10  C8y C    28.4200  -24.8500
            11  C8x C    29.6100  -24.1500
            12  C8y C    30.8700  -24.7800
            13  C8x C    30.8700  -26.1800
            14  C8x C    29.6800  -26.8800
            15  C1c C    32.0600  -24.0800
            16  C1a C    32.0600  -22.6800
            17  C6a C    33.2500  -24.7800
            18  O6a O    34.4400  -24.0800
            19  O6a O    33.2500  -26.1800
BOND        21
            1     5   4 2
            2     4   1 1
            3     1   2 2
            4     2   3 1
            5     3   6 2
            6     9  10 2
            7    10  11 1
            8    11  12 2
            9    12  13 1
            10   13  14 2
            11   14   9 1
            12    5   6 1
            13   12  15 1
            14    6   7 1
            15   15  16 1
            16    7  10 1
            17   15  17 1
            18    9   8 1
            19   17  18 1
            20    8   5 1
            21   17  19 2

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