KEGG   DRUG: Hydrocortisone butyrate
Entry
D01619                      Drug                                   

Name
Hydrocortisone butyrate (JP17/USP);
Locoid (TN)
Product
  Generic
Formula
C25H36O6
Exact mass
432.2512
Mol weight
432.5497
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 2646
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07AB02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Seborrheic dermatitis [DS:H01652]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
    D07AB Corticosteroids, moderately potent (group II)
     D07AB02 Hydrocortisone butyrate
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Hydrocortisone
     D01619  Hydrocortisone butyrate (JP17/USP)
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D01619  Hydrocortisone butyrate (JP17/USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D01619  Hydrocortisone butyrate (JP17/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D01619  Hydrocortisone butyrate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01619  Hydrocortisone butyrate (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01619  Hydrocortisone butyrate (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone butyrate
    D01619  Hydrocortisone butyrate (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone butyrate
    D01619  Hydrocortisone butyrate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01619  Hydrocortisone butyrate (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01619  Hydrocortisone butyrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01619
Topical steroids potency [br08317.html]
 Classification in the USA
  D01619
 Classification in Japan
  D01619
Rx-to-OTC switch list in Japan [br08314.html]
 D01619
Other DBs
CAS: 13609-67-1
PubChem: 7848682
ChEBI: 31674
ChEMBL: CHEMBL1683
LigandBox: D01619
NIKKAJI: J8.130B
LinkDB
KCF data

ATOM        31
            1   C1z C    23.4455  -15.4741
            2   C1y C    23.4632  -16.8359
            3   C1z C    24.6253  -14.7814
            4   C1x C    22.2892  -14.7991
            5   C1y C    22.3069  -17.5227
            6   C1x C    25.8286  -16.8824
            7   C1x C    25.8169  -15.4506
            8   C5a C    24.6136  -13.4138
            9   O7a O    25.9754  -14.4939
            10  C1y C    21.0976  -15.4918
            11  C1y C    21.1036  -16.8476
            12  C1x C    22.3069  -18.8845
            13  C1b C    25.8581  -12.7564
            14  O5a O    23.3868  -12.7035
            15  O1a O    19.8767  -14.7874
            16  C1z C    19.9472  -17.5285
            17  C1x C    21.1270  -19.5712
            18  O1a O    27.0672  -13.5018
            19  C2y C    19.9590  -18.8963
            20  C1x C    18.7614  -16.8594
            21  C2x C    18.7732  -19.5889
            22  C1x C    17.5758  -17.5402
            23  C5x C    17.5581  -18.9783
            24  O5x O    16.3665  -19.6182
            25  C7a C    27.1852  -15.1923
            26  C1b C    28.3980  -14.4902
            27  C1b C    29.6109  -15.1923
            28  C1a C    30.8237  -14.4902
            29  O6a O    27.1860  -16.5967
            30  C1a C    23.3905  -14.2074
            31  C1a C    19.9850  -16.2632
BOND        34
            1     3   8 1 #Up
            2     3   9 1 #Down
            3     4  10 1
            4     5  11 1
            5     5  12 1
            6     8  13 1
            7     8  14 2
            8    10  15 1 #Up
            9    11  16 1
            10   12  17 1
            11   13  18 1
            12   16  19 1
            13   16  20 1
            14   19  21 2
            15   20  22 1
            16   21  23 1
            17   23  24 2
            18    6   7 1
            19   10  11 1
            20   17  19 1
            21   22  23 1
            22    9  25 1
            23    1   2 1
            24   25  26 1
            25    1   3 1
            26   26  27 1
            27    1   4 1
            28   27  28 1
            29    2   5 1
            30   25  29 2
            31    2   6 1
            32    1  30 1 #Up
            33    3   7 1
            34   16  31 1 #Up

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