KEGG   DRUG: Felbinac
Entry
D01675                      Drug                                   

Name
Felbinac (JP17/USAN/INN);
Dolinac (TN);
Felbinac (TN)
Formula
C14H12O2
Exact mass
212.0837
Mol weight
212.2439
Structure
Simcomp
Class
Anti-inflammatory
 DG01906  Anti-inflammatory drug, acetic acid derivatives
  DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
   DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
Remark
Therapeutic category: 2649
ATC code: M02AA08
Chemical structure group: DG00764
Product (DG00764): D01675<JP>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Phenylacetic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA08 Felbinac
      D01675  Felbinac (JP17/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D01675  Felbinac (JP17/USAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01675  Felbinac (JP17/USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Felbinac
    D01675  Felbinac (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01675  Felbinac (JP17/USAN/INN) <JP>
    PTGS2 (COX2)
     D01675  Felbinac (JP17/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01675 Felbinac
  D01675  Felbinac tape
  D01675  Felbinac cataplasm
Rx-to-OTC switch list in Japan [br08314.html]
 D01675
Other DBs
CAS: 5728-52-9
PubChem: 7848738
ChEBI: 31597
ChEMBL: CHEMBL413965
PDB-CCD: BP4[PDBj]
LigandBox: D01675
NIKKAJI: J105.145H
LinkDB
KCF data

ATOM        16
            1   C8x C    18.2700  -14.2800
            2   C8x C    18.2700  -15.6800
            3   C8x C    19.4824  -16.3800
            4   C8x C    20.6949  -15.6800
            5   C8y C    20.6949  -14.2800
            6   C8x C    19.4824  -13.5800
            7   C8y C    21.9260  -13.5690
            8   C8x C    23.1312  -14.2647
            9   C8x C    24.3435  -13.5646
            10  C8y C    24.3435  -12.1646
            11  C8x C    23.1383  -11.4689
            12  C8x C    21.9259  -12.1690
            13  C1b C    25.5614  -11.4612
            14  C6a C    26.7734  -12.1607
            15  O6a O    27.9523  -11.4798
            16  O6a O    26.7740  -13.5796
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 2

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