KEGG   DRUG: Loxoprofen sodium hydrate
Entry
D01709                      Drug                                   

Name
Loxoprofen sodium hydrate (JP17);
Lorfenamin (TN);
Loxonin (TN)
Formula
C15H17O3. 2H2O. Na
Exact mass
304.1287
Mol weight
304.314
Structure
Simcomp
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
Therapeutic category: 1149 2649
Chemical structure group: DG01251
Product (DG01251): D01709<JP>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
PTGS1 (COX1) [HSA:5742] [KO:K00509]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01709  Loxoprofen sodium hydrate (JP17)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D01709  Loxoprofen sodium hydrate (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  03 Antipyretic analgesic agents
   D01709  Loxoprofen sodium hydrate (JP17)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Loxoprofen
    D01709  Loxoprofen sodium hydrate (JP17)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Loxoprofen
    D01709  Loxoprofen sodium hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01709  Loxoprofen sodium hydrate (JP17) <JP>
    PTGS2 (COX2)
     D01709  Loxoprofen sodium hydrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01709  Loxoprofen sodium hydrate
  D01709  Loxoprofen sodium tablets
Rx-to-OTC switch list in Japan [br08314.html]
 D01709
Other DBs
CAS: 80382-23-6
PubChem: 7848772
ChEBI: 31786
LigandBox: D01709
NIKKAJI: J22.352B
LinkDB
KCF data

ATOM        21
            1   Z   Na   36.0934  -14.4362 #+
            2   O0  O    40.3165  -16.1141
            3   C8y C    28.4875  -16.4943
            4   C8x C    29.6970  -17.1967
            5   C8x C    30.8451  -16.4964
            6   C8y C    30.8710  -15.0910
            7   C8x C    29.7023  -14.3861
            8   C8x C    28.4839  -15.0864
            9   C1c C    32.1364  -14.3908
            10  C6a C    33.3521  -15.0956
            11  C1a C    32.1390  -12.9854
            12  O6a O    34.5705  -14.3954 #-
            13  O6a O    33.3263  -16.4541
            14  C1x C    26.0590  -15.0926
            15  C1y C    26.0627  -16.5005
            16  C1b C    27.2769  -17.1974
            17  C1x C    24.7189  -14.6610
            18  C1x C    23.8943  -15.8021
            19  C5x C    24.7248  -16.9390
            20  O5x O    24.2939  -18.2767
            21  O0  O    40.3165  -16.1141
BOND        19
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     8   3 1
            7     6   9 1
            8     9  10 1
            9     9  11 1
            10   10  12 1
            11   10  13 2
            12   14  15 1
            13   15  16 1
            14    3  16 1
            15   14  17 1
            16   17  18 1
            17   18  19 1
            18   15  19 1
            19   19  20 2
BRACKET     1    38.2900  -17.0800   38.2900  -15.2600
            1    41.0200  -15.2600   41.0200  -17.0800
            1  2
 ORIGINAL  1    2
 REPEAT    1   21

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