| Entry |
|
|---|
| Name |
Sapropterin dihydrochloride (USAN);
Sapropterin hydrochloride (JAN);
Biopten (TN);
Kuvan (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C9H15N5O3. 2HCl
|
|---|
| Exact mass |
313.0708
|
|---|
| Mol weight |
314.169
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Remark |
| Therapeutic category: | 3999 |
| Product (DG00147): | D01798<JP/US> |
|
|---|
| Efficacy |
Antihyperphenylalaninemia, Cofactor replacement (tetrahydrobiopterin) |
|---|
| Disease |
Phenylketonuria, BH4-responsive [DS: H00167] |
|---|
| Comment |
Cofactor replacement
Treatment of mild-to-moderate phenylketonuria (PKU)
|
|---|
| Target |
|
|---|
| Network |
| N10019 | Replacement of cofactor BH4 for deficient QDPR |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16AX Various alimentary tract and metabolism products
A16AX07 Sapropterin
D01798 Sapropterin dihydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
Sapropterin
D01798 Sapropterin dihydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
399 Miscellaneous
3999 Others
D01798 Sapropterin dihydrochloride (USAN); Sapropterin hydrochloride (JAN)
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01798
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01798
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01798
Pharmacogenomic biomarkers [br08341.html]
Germline mutations in genetic disorder treatments
D01798
|
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| Other DBs |
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| LinkDB |
|
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| KCF data |
ATOM 19
1 N5x N 19.7015 -17.4044
2 C8y C 19.7015 -18.8056
3 N4x N 20.9179 -19.5062
4 C8y C 20.9179 -16.7038
5 C8y C 22.1272 -17.4044
6 C8y C 22.1211 -18.8056
7 N1x N 23.3315 -19.5114
8 C1x C 24.5481 -18.8159
9 C1y C 24.5541 -17.4147
10 N1x N 23.3436 -16.7090
11 C1c C 25.7591 -16.7180
12 C1c C 26.9692 -17.4186
13 C1a C 28.1793 -16.7250
14 O1a O 26.9661 -18.8198
15 O1a O 25.7596 -15.3169
16 N1a N 18.4884 -19.5068
17 O5x O 20.9196 -15.3026
18 X Cl 31.9459 -17.9706
19 X Cl 31.9459 -17.9706
BOND 18
1 8 9 1
2 9 10 1
3 10 5 1
4 4 1 1
5 9 11 1
6 11 12 1
7 12 13 1
8 1 2 2
9 12 14 1 #Down
10 2 3 1
11 11 15 1 #Up
12 3 6 1
13 2 16 1
14 5 4 1
15 4 17 2
16 5 6 2
17 6 7 1
18 7 8 1
BRACKET 1 30.8700 -18.9700 30.8700 -17.0800
1 32.5500 -17.0800 32.5500 -18.9700
1 2
ORIGINAL 1 19
REPEAT 1 20
|
|---|
