KEGG   DRUG: Dexamethasone valerate
Entry
D01948                      Drug                                   

Name
Dexamethasone valerate (JAN);
Dexamethasone 17-valerate;
DV-17;
Voalla ointment (TN)
Formula
C27H37FO6
Exact mass
476.2574
Mol weight
476.5775
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 2646
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D01948  Dexamethasone valerate (JAN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D01948  Dexamethasone valerate (JAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D01948  Dexamethasone valerate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01948  Dexamethasone valerate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01948  Dexamethasone valerate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01948
Topical steroids potency [br08317.html]
 Classification in Japan
  D01948
Other DBs
CAS: 33755-46-3
PubChem: 7849010
ChEMBL: CHEMBL1378167
DrugBank: DB01234
LigandBox: D01948
NIKKAJI: J67.028F
LinkDB
KCF data

ATOM        34
            1   C2x C    14.8604  -19.2419
            2   C5x C    14.8604  -20.6015
            3   C2x C    16.0379  -21.2814
            4   C2y C    17.2153  -20.6015
            5   C1z C    17.2153  -19.2419
            6   C2x C    16.0379  -18.5620
            7   C1x C    18.3928  -21.2814
            8   C1x C    19.5703  -20.6015
            9   C1y C    19.5703  -19.2419
            10  C1z C    18.3928  -18.5620
            11  C1y C    20.7478  -18.5620
            12  C1z C    20.7478  -17.2024
            13  C1x C    19.5703  -16.5225
            14  C1y C    18.3928  -17.2024
            15  C1x C    23.1028  -18.5620
            16  C1y C    23.1028  -17.2024
            17  C1z C    21.9253  -16.5225
            18  C5a C    21.9306  -14.8129
            19  C1b C    20.7531  -14.1331
            20  O1a O    19.5756  -14.7195
            21  O5a O    23.1236  -14.1271
            22  O7a O    23.1363  -15.8333
            23  C7a C    24.9581  -15.8333
            24  O6a O    25.6590  -17.0472
            25  C1b C    25.6590  -14.6193
            26  C1b C    27.0609  -14.6193
            27  C1b C    27.7612  -13.4063
            28  C1a C    29.1566  -13.4063
            29  C1a C    24.5273  -17.1841
            30  X   F    18.4084  -19.9867
            31  O5x O    13.6486  -21.3012
            32  C1a C    17.1938  -17.8381
            33  O1a O    17.1832  -16.5039
            34  C1a C    20.7438  -15.8762
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   18  19 1
            23   19  20 1
            24   18  21 2
            25   17  22 1 #Down
            26   22  23 1
            27   23  24 2
            28   23  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   16  29 1 #Down
            33   10  30 1 #Down
            34    2  31 2
            35    5  32 1 #Up
            36   14  33 1 #Up
            37   12  34 1 #Up

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