KEGG   DRUG: Zoledronic acid
Entry
D01968                      Drug                                   
Name
Zoledronic acid (USAN);
Zoledronic acid hydrate (JAN);
Zometa (TN);
Reclast (TN)
Product
RECLAST (Novartis Pharmaceuticals Corporation), ZOLEDRONIC ACID (Sagent Pharmaceuticals), ZOLEDRONIC ACID (Sagent Pharmaceuticals)
  Generic
ZOLEDRONIC ACID (Accord Healthcare), ZOLEDRONIC ACID (Akorn), ZOLEDRONIC ACID (Akorn), ZOLEDRONIC ACID (Apotex Corp), ZOLEDRONIC ACID (Athenex Pharmaceutical Division), ZOLEDRONIC ACID (Athenex Pharmaceutical Division), ZOLEDRONIC ACID (AuroMedics Pharma LLC), ZOLEDRONIC ACID (AuroMedics Pharma LLC), ZOLEDRONIC ACID (BPI Labs), ZOLEDRONIC ACID (BluePoint Laboratories), ZOLEDRONIC ACID (Dr. Reddy's Laboratories), ZOLEDRONIC ACID (Dr. Reddy's Laboratories), ZOLEDRONIC ACID (Dr. Reddy's Laboratories Limited), ZOLEDRONIC ACID (Dr.Reddy's Laboratories), ZOLEDRONIC ACID (Dr.Reddy's Laboratories), ZOLEDRONIC ACID (Fresenius Kabi USA), ZOLEDRONIC ACID (Fresenius Kabi USA), ZOLEDRONIC ACID (Gland Pharma Limited), ZOLEDRONIC ACID (Gland Pharma Limited), ZOLEDRONIC ACID (Gland Pharma Limited), ZOLEDRONIC ACID (Gland Pharma Limited), ZOLEDRONIC ACID (Hikma Pharmaceuticals USA), ZOLEDRONIC ACID (Hospira), ZOLEDRONIC ACID (Ingenus Pharmaceuticals), ZOLEDRONIC ACID (Mylan Institutional LLC), ZOLEDRONIC ACID (Mylan Institutional LLC), ZOLEDRONIC ACID (Mylan Institutional LLC), ZOLEDRONIC ACID (Mylan Institutional LLC), ZOLEDRONIC ACID (Northstar RxLLC), ZOLEDRONIC ACID (Sagent Pharmaceuticals), ZOLEDRONIC ACID (Sagent Pharmaceuticals)
Formula
C5H10N2O7P2. H2O
Exact mass
290.0069
Mol weight
290.1049
Structure
Simcomp
Class
Musculo-skeletal system agent
 DG03232  Osteoporosis agent
  DG01600  Bisphosphonate
Remark
Therapeutic category: 3999
ATC code: M05BA08
Chemical structure group: DG00787
Product (DG00787): D01968<JP/US>
Efficacy
Antihypercalcemia, Antiresorptive, Farnesylpyrophosphate synthetase inhibitor
  Disease
Osteoporosis [DS:H01593]
Glucocorticoid-induced osteoporosis [DS:H01709]
Paget's disease of bone [DS:H00437]
Multiple myeloma [DS:H00010]
Comment
Bisphosphonate
Target
FDPS [HSA:2224] [KO:K00787]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Interaction
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BA Bisphosphonates
     M05BA08 Zoledronic acid
      D01968  Zoledronic acid (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Treatment Adjuncts
   Zoledronic Acid
    D01968  Zoledronic acid (USAN)
 Metabolic Bone Disease Agents
  Bisphosphonates
   Zoledronic Acid
    D01968  Zoledronic acid (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01968  Zoledronic acid (USAN); Zoledronic acid hydrate (JAN)
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG01600  Bisphosphonate
    DG00787  Zoledronic acid
     D01968  Zoledronic acid
Drug classes [BR:br08332]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   D01968  Zoledronic acid
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Alkyl/Aryl transferases
    FDPS
     D01968  Zoledronic acid (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01968
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01968
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01968
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01968
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG01600  Bisphosphonate
    DG00787  Zoledronic acid
Other DBs
CAS: 165800-06-6
PubChem: 7849030
LigandBox: D01968
LinkDB
KCF data

ATOM        17
            1   O0  O    28.8400  -25.1300
            2   C1d C    23.3100  -23.8000
            3   P1b P    24.5700  -24.4300
            4   P1b P    22.1200  -24.4300
            5   C1b C    23.3100  -22.4000
            6   O1c O    20.9300  -23.8000
            7   O1c O    22.1200  -25.8300
            8   O1c O    20.5800  -25.4100
            9   O1c O    25.6900  -23.8000
            10  O1c O    24.5700  -25.8300
            11  O1c O    25.6900  -25.1300
            12  O1a O    23.3100  -25.2000
            13  N4y N    24.5000  -21.7000
            14  C8x C    25.8300  -22.1200
            15  N5x N    26.6700  -21.0000
            16  C8x C    25.8300  -19.8800
            17  C8x C    24.5000  -20.3000
BOND        16
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     4   6 2
            5     4   7 1
            6     4   8 1
            7     3   9 2
            8     3  10 1
            9     3  11 1
            10    2  12 1
            11    5  13 1
            12   13  14 1
            13   14  15 2
            14   15  16 1
            15   16  17 2
            16   13  17 1

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