KEGG   DRUG: Zoledronic acid
Entry
D01968                      Drug                                   
Name
Zoledronic acid (USAN);
Zoledronic acid hydrate (JAN);
Zometa (TN);
Reclast (TN)
Product
  Generic
Formula
C5H10N2O7P2. H2O
Exact mass
290.0069
Mol weight
290.1049
Structure
Simcomp
Class
Musculo-skeletal system agent
 DG03232  Osteoporosis agent
  DG01600  Bisphosphonate
Remark
Therapeutic category: 3999
ATC code: M05BA08
Chemical structure group: DG00787
Product (DG00787): D01968<JP/US>
Efficacy
Antihypercalcemia, Antiresorptive, Farnesylpyrophosphate synthetase inhibitor
  Disease
Osteoporosis [DS:H01593]
Glucocorticoid-induced osteoporosis [DS:H01709]
Paget's disease of bone [DS:H00437]
Multiple myeloma [DS:H00010]
Comment
Bisphosphonate
Target
FDPS [HSA:2224] [KO:K00787]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Interaction
Structure map
map07047  Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BA Bisphosphonates
     M05BA08 Zoledronic acid
      D01968  Zoledronic acid (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Treatment Adjuncts
   Zoledronic Acid
    D01968  Zoledronic acid (USAN)
 Metabolic Bone Disease Agents
  Bisphosphonates
   Zoledronic Acid
    D01968  Zoledronic acid (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01968  Zoledronic acid (USAN); Zoledronic acid hydrate (JAN)
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG01600  Bisphosphonate
    DG00787  Zoledronic acid
     D01968  Zoledronic acid
Drug classes [BR:br08332]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   D01968  Zoledronic acid
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Alkyl/Aryl transferases
    FDPS
     D01968  Zoledronic acid (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01968
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01968
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01968
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01968
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG01600  Bisphosphonate
    DG00787  Zoledronic acid
Other DBs
CAS: 165800-06-6
PubChem: 7849030
LigandBox: D01968
LinkDB
KCF data

ATOM        17
            1   O0  O    28.8400  -25.1300
            2   C1d C    23.3100  -23.8000
            3   P1b P    24.5700  -24.4300
            4   P1b P    22.1200  -24.4300
            5   C1b C    23.3100  -22.4000
            6   O1c O    20.9300  -23.8000
            7   O1c O    22.1200  -25.8300
            8   O1c O    20.5800  -25.4100
            9   O1c O    25.6900  -23.8000
            10  O1c O    24.5700  -25.8300
            11  O1c O    25.6900  -25.1300
            12  O1a O    23.3100  -25.2000
            13  N4y N    24.5000  -21.7000
            14  C8x C    25.8300  -22.1200
            15  N5x N    26.6700  -21.0000
            16  C8x C    25.8300  -19.8800
            17  C8x C    24.5000  -20.3000
BOND        16
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     4   6 2
            5     4   7 1
            6     4   8 1
            7     3   9 2
            8     3  10 1
            9     3  11 1
            10    2  12 1
            11    5  13 1
            12   13  14 1
            13   14  15 2
            14   15  16 1
            15   16  17 2
            16   13  17 1

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