KEGG   DRUG: Prednisolone farnesylate
Entry
D01998                      Drug                                   

Name
Prednisolone farnesylate (JAN);
PNF 21;
Farnerate (TN)
Formula
C36H50O6
Exact mass
578.3607
Mol weight
578.7786
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
 DG01985  Disease modifying anti-rheumatic drugs (DMARDs)
Remark
ATC code: A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01998  Prednisolone farnesylate (JAN)
Other DBs
CAS: 118244-44-3
PubChem: 7849060
ChEBI: 32043
ChEMBL: CHEMBL3188458
DrugBank: DB00860
LigandBox: D01998
NIKKAJI: J510.522F
LinkDB
KCF data

ATOM        42
            1   C1y C    30.8122  -21.1038
            2   C1y C    29.6006  -21.7562
            3   C1z C    30.8122  -19.7057
            4   C1x C    33.2356  -21.1038
            5   C1y C    28.4355  -21.0571
            6   C1x C    29.6006  -23.1543
            7   C1z C    32.0239  -19.0532
            8   C1x C    29.6472  -19.0066
            9   C1a C    30.7656  -18.4940
            10  C1x C    33.2356  -19.7523
            11  C1z C    27.2238  -21.7562
            12  C1y C    28.4355  -19.7057
            13  C1x C    28.3889  -23.8534
            14  C5a C    32.0239  -17.6551
            15  O1a O    33.3288  -18.6804
            16  C2y C    27.2238  -23.1543
            17  C2x C    26.0121  -21.0571
            18  C1a C    27.2238  -20.4514
            19  O1a O    27.2238  -19.0066
            20  C1b C    33.1890  -16.9561
            21  O5a O    30.8122  -16.9561
            22  C2x C    26.0121  -23.8534
            23  C2x C    24.8471  -21.7562
            24  O7a O    34.4007  -17.6551
            25  C5x C    24.8471  -23.1543
            26  C7a C    35.5657  -16.9561
            27  O5x O    23.6353  -23.8534
            28  C2b C    36.7775  -17.6551
            29  O6a O    35.5657  -15.5579
            30  C2c C    37.9891  -16.9561
            31  C1b C    39.2008  -17.6551
            32  C1b C    40.3658  -16.9561
            33  C1a C    37.9891  -15.5554
            34  C2b C    41.5583  -17.6644
            35  C2c C    42.7708  -16.9643
            36  C1b C    43.9834  -17.6644
            37  C1b C    45.1960  -16.9643
            38  C2b C    46.4086  -17.6644
            39  C1a C    42.7708  -15.5641
            40  C2c C    47.6246  -16.9624
            41  C1a C    48.8395  -17.6638
            42  C1a C    47.6246  -15.5641
BOND        45
            1     3   7 1
            2     3   8 1
            3     3   9 1 #Up
            4     4  10 1
            5     5  11 1
            6     5  12 1
            7     6  13 1
            8     7  14 1 #Up
            9     7  15 1 #Down
            10   11  16 1
            11   11  17 1
            12   11  18 1 #Up
            13   12  19 1 #Up
            14   14  20 1
            15   14  21 2
            16   16  22 2
            17   17  23 2
            18   20  24 1
            19   22  25 1
            20   24  26 1
            21   25  27 2
            22   26  28 1
            23   26  29 2
            24    7  10 1
            25    8  12 1
            26   13  16 1
            27   23  25 1
            28    1   2 1
            29   28  30 2
            30    1   3 1
            31   30  31 1
            32    1   4 1
            33   31  32 1
            34    2   5 1
            35    2   6 1
            36   30  33 1
            37   32  34 1
            38   34  35 2
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   35  39 1
            43   38  40 2
            44   40  41 1
            45   40  42 1

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