KEGG   DRUG: Tranilast
Entry
D02027                      Drug                                   

Name
Tranilast (JP17/USAN/INN);
Rizaben (TN)
Formula
C18H17NO5
Exact mass
327.1107
Mol weight
327.3313
Structure
Simcomp
Class
Anti-allergic agent
 DG01805  Mediator release inhibitor
Remark
Therapeutic category: 1319 4490
Product: D02027<JP>
Efficacy
Antiallergic, Antiasthmatic, Mediator release inhibitor
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D02027  Tranilast (JP17/USAN/INN)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D02027  Tranilast (JP17/USAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  64 Allergy eye drops
   D02027  Tranilast (JP17/USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Tranilast
    D02027  Tranilast (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02027  Tranilast
  D02027  Tranilast capsules
  D02027  Tranilast fine granules
  D02027  Tranilast for syrup
  D02027  Tranilast ophthalmic solution
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02027
Rx-to-OTC switch list in Japan [br08314.html]
 D02027
Other DBs
CAS: 53902-12-8
PubChem: 7849089
ChEBI: 77572
ChEMBL: CHEMBL415324
PDB-CCD: D27[PDBj]
LigandBox: D02027
NIKKAJI: J1.065K
LinkDB
KCF data

ATOM        24
            1   C8y C    21.9358  -16.1486
            2   C8y C    21.9358  -14.7490
            3   N1b N    23.1488  -16.8483
            4   C8x C    20.7230  -16.8483
            5   C8x C    20.7230  -14.0492
            6   C6a C    23.1488  -14.0492
            7   C5a C    23.1488  -18.2478
            8   C8x C    19.5100  -16.1486
            9   C8x C    19.5100  -14.7490
            10  O6a O    24.3151  -14.7490
            11  O6a O    23.1488  -12.6496
            12  C2b C    24.3151  -18.9476
            13  O5a O    21.8892  -18.9476
            14  C2b C    24.3151  -20.3471
            15  C8y C    25.5280  -21.0468
            16  C8x C    25.5280  -22.4464
            17  C8x C    26.7409  -20.3471
            18  C8x C    26.7409  -23.1462
            19  C8y C    27.9538  -21.0468
            20  C8y C    27.9538  -22.4464
            21  O2a O    29.1668  -23.1462
            22  C1a C    30.3991  -22.4344
            23  O2a O    29.1862  -20.3352
            24  C1a C    30.3917  -21.0312
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   12  14 2
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 2
            20   20  21 1
            21    8   9 2
            22   19  20 1
            23   21  22 1
            24   19  23 1
            25   23  24 1

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