KEGG   DRUG: Betamethasone butyrate propionate
Entry
D02032                      Drug                                   

Name
Betamethasone butyrate propionate (JAN);
Antebate (TN)
Formula
C29H39FO7
Exact mass
518.268
Mol weight
518.6142
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Product (mixture): D10788<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D02032  Betamethasone butyrate propionate (JAN) <JP>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Betamethasone
     D02032  Betamethasone butyrate propionate (JAN)
   Glucocorticoids, High Potency
    Betamethasone
     D02032  Betamethasone butyrate propionate (JAN)
   Glucocorticoids, Very High Potency
    Betamethasone
     D02032  Betamethasone butyrate propionate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D02032  Betamethasone butyrate propionate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02032  Betamethasone butyrate propionate (JAN) <JP>
Topical steroids potency [br08317.html]
 Classification in Japan
  D02032
Other DBs
CAS: 5534-02-1
PubChem: 7849094
ChEMBL: CHEMBL1697785
DrugBank: DB00443
LigandBox: D02032
NIKKAJI: J277.648K
LinkDB
KCF data

ATOM        37
            1   C2x C    15.6561  -19.4690
            2   C5x C    15.6561  -20.8194
            3   C2x C    16.8256  -21.4948
            4   C2y C    17.9952  -20.8194
            5   C1z C    17.9952  -19.4690
            6   C2x C    16.8256  -18.7937
            7   C1x C    19.1647  -21.4948
            8   C1x C    20.3344  -20.8194
            9   C1y C    20.3344  -19.4690
            10  C1z C    19.1647  -18.7937
            11  C1y C    21.5039  -18.7937
            12  C1z C    21.5039  -17.4432
            13  C1x C    20.3344  -16.7679
            14  C1y C    19.1647  -17.4432
            15  C1x C    23.8430  -18.7937
            16  C1y C    23.8430  -17.4432
            17  C1z C    22.6735  -16.7679
            18  C1a C    25.2197  -17.4517
            19  C5a C    22.6737  -15.0019
            20  C1a C    21.4866  -16.0984
            21  O1a O    17.9476  -16.7404
            22  C1a C    17.9831  -18.0546
            23  O5x O    14.4453  -21.5185
            24  X   F    19.1493  -20.2006
            25  O7a O    23.9078  -16.0487
            26  O5a O    23.9029  -14.2923
            27  C1b C    21.4828  -14.2991
            28  O7a O    20.2708  -14.9989
            29  C7a C    19.0588  -14.2991
            30  C1b C    17.8467  -14.9989
            31  O6a O    19.0588  -12.8996
            32  C1a C    16.6320  -14.2975
            33  C7a C    26.0073  -16.0487
            34  O6a O    26.7103  -17.2661
            35  C1b C    26.6970  -14.8538
            36  C1b C    28.0922  -14.8536
            37  C1a C    28.7947  -13.6363
BOND        40
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   16  18 1 #Up
            22   17  19 1 #Up
            23   12  20 1 #Up
            24   14  21 1 #Up
            25    5  22 1 #Up
            26    2  23 2
            27   10  24 1 #Down
            28   17  25 1 #Down
            29   19  26 2
            30   19  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 1
            36   25  33 1
            37   33  34 2
            38   33  35 1
            39   35  36 1
            40   36  37 1

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