KEGG   DRUG: Milrinone lactate
Entry
D02085                      Drug                                   

Name
Milrinone lactate;
Primacor (TN)
Product
  Generic
Formula
C12H9N3O. (C3H6O3)x
Structure
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01757  Amrinone type cardiotonic
 DG01507  Phosphodiesterase III inhibitor
  DG01757  Amrinone type cardiotonic
Remark
ATC code: C01CE02
Chemical structure group: DG00229
Product (DG00229): D00417<JP> D02085<US>
Efficacy
Cardiotonic, Phosphodiesterase 3 inhibitor
  Disease
Acute decompensated heart failure [DS:H01631]
Comment
Amrinone derivative
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296]
  Pathway
hsa00230  Purine metabolism
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04371  Apelin signaling pathway
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CE Phosphodiesterase inhibitors
     C01CE02 Milrinone
      D02085  Milrinone lactate <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    PDE3
     D02085  Milrinone lactate <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02085
Other DBs
CAS: 100286-97-3
PubChem: 7849146
ChEBI: 34850
ChEMBL: CHEMBL1200977
DrugBank: DB00235
LigandBox: D02085
NIKKAJI: J2.203.864H
LinkDB
KCF data

ATOM        22
            1   C8y C    27.4735  -17.2583
            2   C8y C    28.6858  -16.5588
            3   C8x C    26.2669  -16.5588
            4   C8y C    27.4735  -18.6570
            5   C8x C    29.8983  -17.2583
            6   C8x C    28.6858  -15.1599
            7   C8y C    25.0487  -17.2583
            8   N4x N    26.2669  -19.3624
            9   C1a C    28.6801  -19.3565
            10  C8x C    31.1165  -16.5705
            11  C8x C    29.9040  -14.4604
            12  C8y C    25.0487  -18.6570
            13  C3b C    23.8364  -16.5588
            14  N5x N    31.1165  -15.1599
            15  O5x O    23.8364  -19.3624
            16  N3a N    22.6239  -15.8594
            17  C1c C    36.8899  -17.6785
            18  C6a C    38.0965  -16.9908
            19  C1a C    36.8840  -19.0833
            20  O1a O    35.6776  -16.9849
            21  O6a O    38.0905  -15.5919
            22  O6a O    39.3088  -17.6901
BOND        22
            1     2   6 1
            2     3   7 2
            3     4   8 1
            4     4   9 1
            5     5  10 1
            6     6  11 2
            7     7  12 1
            8     7  13 1
            9    10  14 2
            10   12  15 2
            11   13  16 3
            12    8  12 1
            13   11  14 1
            14    1   2 1
            15    1   3 1
            16    1   4 2
            17    2   5 2
            18   17  18 1
            19   17  19 1
            20   17  20 1
            21   18  21 2
            22   18  22 1
BRACKET     1    34.0200  -19.8800   34.0200  -14.7000
            1    40.8100  -14.7000   40.8100  -19.8800
            1  x
 ORIGINAL  1   17  18  19  20  21  22
 REPEAT    1

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