KEGG   DRUG: Epinephrine bitartrate
Entry
D02149                      Drug                                   

Name
Epinephrine bitartrate (JAN/USP);
Asmatane mist (TN);
Medihaler-epi (TN)
Formula
C9H13NO3. C4H6O6
Exact mass
333.106
Mol weight
333.2913
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
 DG01592  COMT substrate
Metabolizing enzyme substrate
 DG02917  MAO substrate
Remark
ATC code: A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
Chemical structure group: DG00013
Product (DG00013): D00095<JP/US>
Product (mixture): D04813<JP/US> D04818<US> D11290<US> D11569<US>
Efficacy
Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D02149  Epinephrine bitartrate (JAN/USP)
    ADRA2
     D02149  Epinephrine bitartrate (JAN/USP)
    ADRB
     D02149  Epinephrine bitartrate (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02149
Other DBs
CAS: 51-42-3
PubChem: 7849210
ChEMBL: CHEMBL1200818
DrugBank: DB00668
LigandBox: D02149
NIKKAJI: J231.238G
LinkDB
KCF data

ATOM        23
            1   C8y C    16.7785  -17.0333
            2   C8x C    16.7785  -18.4291
            3   C8x C    15.5689  -16.3355
            4   C1c C    17.9882  -16.3355
            5   C8x C    15.5689  -19.1735
            6   C8y C    14.3592  -17.0333
            7   C1b C    19.1978  -17.0333
            8   O1a O    17.9882  -14.9397
            9   C8y C    14.3592  -18.4291
            10  N1b N    20.4074  -16.3355
            11  O1a O    13.1496  -19.1269
            12  O1a O    13.1496  -16.3355
            13  C1a C    21.6171  -17.0333
            14  O6a O    25.0833  -17.0100
            15  C6a C    26.2958  -16.3100
            16  C1c C    27.5082  -17.0100
            17  C1c C    28.7207  -16.3100
            18  C6a C    29.9332  -17.0100
            19  O6a O    31.1456  -16.3100
            20  O6a O    29.9332  -18.4100
            21  O6a O    26.2958  -14.9100
            22  O1a O    28.7207  -14.9100
            23  O1a O    27.5082  -18.4100
BOND        22
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     3   6 2
            5     4   7 1
            6     4   8 1 #Up
            7     5   9 2
            8     7  10 1
            9     9  11 1
            10    6   9 1
            11    6  12 1
            12    1   2 2
            13   10  13 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   18  20 2
            20   15  21 2
            21   17  22 1 #Up
            22   16  23 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system