KEGG   DRUG: Prednisolone hemisuccinate
Entry
D02156                      Drug                                   

Name
Prednisolone hemisuccinate (USP);
Prednisolone succinate (JP17)
Formula
C25H32O8
Exact mass
460.2097
Mol weight
460.5168
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02156  Prednisolone hemisuccinate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02156  Prednisolone succinate
Other DBs
CAS: 2920-86-7
PubChem: 7849217
ChEMBL: CHEMBL1550740 CHEMBL485659
DrugBank: DB00860
LigandBox: D02156
NIKKAJI: J7.936G
LinkDB
KCF data

ATOM        33
            1   C1y C    21.8417  -19.6680
            2   C1y C    20.6301  -20.3204
            3   C1z C    21.8417  -18.2700
            4   C1x C    24.2649  -19.6680
            5   C1y C    19.4651  -19.6214
            6   C1x C    20.6301  -21.7184
            7   C1z C    23.0533  -17.6176
            8   C1x C    20.6767  -17.5710
            9   C1x C    24.2649  -18.3166
            10  C1z C    18.2535  -20.3204
            11  C1y C    19.4651  -18.2700
            12  C1x C    19.4185  -22.4173
            13  C5a C    23.0533  -15.8696
            14  C2y C    18.2535  -21.7184
            15  C2x C    17.0419  -19.6214
            16  O1a O    18.2535  -17.5710
            17  C1b C    24.2183  -15.1706
            18  O5a O    21.8417  -15.1706
            19  C2x C    17.0419  -22.4173
            20  C2x C    15.8770  -20.3204
            21  O7a O    25.4298  -15.8696
            22  C5x C    15.8770  -21.7184
            23  C7a C    26.5948  -15.1706
            24  O5x O    14.6654  -22.4173
            25  C1b C    27.8064  -15.8696
            26  O6a O    26.5948  -13.7727
            27  C1b C    29.0180  -15.1706
            28  C6a C    30.2296  -15.8696
            29  O6a O    31.3946  -15.1706
            30  O6a O    30.2296  -17.2676
            31  C1a C    21.8417  -16.8700
            32  C1a C    18.2535  -18.9204
            33  O1a O    24.2657  -16.9176
BOND        36
            1     3   7 1
            2     3   8 1
            3     4   9 1
            4     5  10 1
            5     5  11 1
            6     6  12 1
            7     7  13 1 #Up
            8    10  14 1
            9    10  15 1
            10   11  16 1 #Up
            11   13  17 1
            12   13  18 2
            13   14  19 2
            14   15  20 2
            15   17  21 1
            16   19  22 1
            17   21  23 1
            18   22  24 2
            19   23  25 1
            20   23  26 2
            21    7   9 1
            22    8  11 1
            23   12  14 1
            24   20  22 1
            25    1   2 1
            26   25  27 1
            27    1   3 1
            28   27  28 1
            29    1   4 1
            30   28  29 1
            31    2   5 1
            32   28  30 2
            33    2   6 1
            34    3  31 1 #Up
            35   10  32 1 #Up
            36    7  33 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system