| Entry |
|
|---|
| Name |
Topotecan hydrochloride (USAN);
Nogitecan hydrochloride (JAN);
Hycamtin (TN);
Potactasol (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C23H23N3O5. HCl
|
|---|
| Exact mass |
457.1404
|
|---|
| Mol weight |
457.9068
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Other
DG01529 Topoisomerase inhibitor
DG01526 Topoisomerase I inhibitor
Transporter substrate
DG01665 ABCB1 (P-GP) substrate
DG02920 ABCC4 substrate
DG01913 ABCG2 (BCRP) substrate
|
|---|
| Remark |
| Therapeutic category: | 4240 |
| Product (DG00725): | D02168<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Topoisomerase I inhibitor |
|---|
| Disease |
|
|---|
| Comment |
Camptothecin [CPD: C01897] derivative
|
|---|
| Target |
|
|---|
| Metabolism |
Transporter: ABCB1 [HSA: 5243], ABCG2 [HSA: 9429], ABCC4 [HSA: 10257]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CE Topoisomerase 1 (TOP1) inhibitors
L01CE01 Topotecan
D02168 Topotecan hydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Enzyme Inhibitors
Topotecan
D02168 Topotecan hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D02168 Topotecan hydrochloride (USAN); Nogitecan hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP1
D02168 Topotecan hydrochloride (USAN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02168
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02168
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D02168
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 32
1 C8y C 32.0215 -19.7287
2 C8y C 29.7683 -20.8552
3 N4y N 30.6133 -19.7285
4 C1x C 29.7683 -18.6020
5 C8y C 28.4540 -20.4326
6 C8y C 28.4540 -19.0244
7 C8x C 27.2336 -18.3673
8 N5x N 27.2336 -21.1367
9 C8y C 26.0131 -20.4796
10 C8y C 26.0131 -19.0714
11 C8y C 24.8396 -18.3673
12 C8y C 23.6191 -19.0714
13 C8x C 23.6191 -20.4796
14 C8x C 24.8396 -21.1838
15 C1b C 24.8396 -17.0060
16 N1c N 23.6191 -16.3019
17 C1a C 23.6191 -14.8937
18 C1a C 22.4456 -17.0060
19 O1a O 22.3987 -18.4143
20 O5x O 32.7141 -18.5298
21 C8y C 32.7340 -20.9631
22 C1x C 34.1280 -20.9630
23 C8y C 32.0340 -22.1755
24 C8x C 30.6115 -22.1758
25 O7x O 34.8251 -22.1700
26 C7x C 34.1346 -23.3658
27 C1z C 32.7215 -23.3659
28 O6a O 34.8251 -24.5616
29 C1b C 31.3147 -23.3660
30 C1a C 30.6287 -24.5679
31 O1a O 32.7215 -24.7659
32 X Cl 36.6837 -19.7288
BOND 35
1 2 3 1
2 3 4 1
3 4 6 1
4 5 2 1
5 5 6 2
6 6 7 1
7 7 10 2
8 9 8 2
9 8 5 1
10 9 10 1
11 10 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 14 9 1
16 11 15 1
17 15 16 1
18 16 17 1
19 16 18 1
20 3 1 1
21 12 19 1
22 1 20 2
23 1 21 1
24 21 22 1
25 21 23 2
26 23 24 1
27 24 2 2
28 22 25 1
29 25 26 1
30 26 27 1
31 27 23 1
32 26 28 2
33 27 29 1 #Down
34 29 30 1
35 27 31 1 #Up
|
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