KEGG   DRUG: Sennosides
Entry
D02171            Mixture   Drug                                   

Name
Sennosides (USP);
Pursennid (TN)
Formula
C42H38O20
Exact mass
862.1956
Mol weight
862.7391
Structure
Simcomp
Component
(Sennoside A [CPD:C10404] | Sennoside A calcium [CPD:C22099]), (Sennoside B [CPD:C13526] | Sennoside B calcium [CPD:C22100])
Source
Senna alexandrina [TAX:72402]
Class
Gastrointestinal agent
 DG01770  Laxative
  DG01765  Contact laxative
Remark
Therapeutic category: 2354 2359
ATC code: A06AB06
Product: D02171<JP>
Efficacy
Laxative
Comment
senna leaf and cane
mixture of Sennoside A and B calcium salt
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AB Contact laxatives
     A06AB06 Senna glycosides
      D02171  Sennosides (USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   235  Purgatives, clysters
    2354  Phytochemical agents
     D02171  Sennosides (USP)
    2359  Others
     D02171  Sennosides (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  17 Cathartics
   D02171  Sennosides (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Sennoside
    D02171  Sennosides (USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Sennoside
    D02171  Sennosides (USP)
Other DBs
CAS: 517-43-1
PubChem: 7849232
ChEBI: 34974
ChEMBL: CHEMBL1314924 CHEMBL1356785 CHEMBL1362935 CHEMBL2368547 CHEMBL445268
LigandBox: D02171
NIKKAJI: J182.274H
LinkDB
KCF data

ATOM        62
            1   C1y C    17.9093  -11.8975
            2   C1y C    17.9092  -15.6249
            3   C8y C    19.0740  -11.2452
            4   C8y C    16.7446  -11.2452
            5   C8y C    19.0740  -16.2772
            6   C8y C    16.7444  -16.2772
            7   C8y C    19.0740   -9.8941
            8   C8x C    20.2388  -11.9441
            9   C8y C    16.7445   -9.8475
            10  C8x C    15.5331  -11.8975
            11  C8y C    19.0740  -17.6749
            12  C8x C    20.2853  -15.6249
            13  C8y C    16.7444  -17.6749
            14  C8x C    15.5330  -15.6249
            15  C5x C    17.9093   -9.1952
            16  C8y C    20.2854   -9.1952
            17  C8y C    21.4502  -11.2452
            18  C8y C    15.5331   -9.1952
            19  C8x C    14.3682  -11.2452
            20  C5x C    17.9092  -18.3272
            21  C8y C    20.2387  -18.3737
            22  C8y C    21.4501  -16.3237
            23  C8y C    15.5330  -18.3272
            24  C8x C    14.3682  -16.2772
            25  O5x O    17.9093   -7.7975
            26  C8x C    21.4502   -9.8941
            27  O1a O    20.2854   -7.8441
            28  C6a C    22.6149  -11.9441
            29  O2a O    15.5331   -7.7975
            30  C8x C    14.3682   -9.8475
            31  O5x O    17.9092  -19.7249
            32  C8x C    21.4501  -17.6749
            33  O1a O    20.2387  -19.7249
            34  C6a C    22.6149  -15.6249
            35  O2a O    15.5330  -19.7249
            36  C8x C    14.3682  -17.6749
            37  O6a O    23.7798  -11.2452
            38  O6a O    22.6149  -13.2952
            39  C1y C    14.3682   -7.1452
            40  O6a O    23.8263  -16.3237
            41  O6a O    22.6149  -14.2737
            42  C1y C    14.3682  -20.3772
            43  O2x O    14.3682   -5.7474
            44  C1y C    13.1569   -7.7975
            45  O2x O    13.1568  -19.6783
            46  C1y C    14.3682  -21.7284
            47  C1y C    13.1569   -5.0951
            48  C1y C    11.9921   -7.1452
            49  O1a O    13.2035   -9.1952
            50  C1y C    11.9920  -20.3772
            51  C1y C    13.1568  -22.4273
            52  O1a O    15.5330  -22.4273
            53  C1y C    11.9921   -5.7941
            54  C1b C    13.1569   -3.7440
            55  O1a O    10.8273   -7.8441
            56  C1y C    11.9920  -21.7284
            57  C1b C    10.7807  -19.6783
            58  O1a O    13.1568  -23.7784
            59  O1a O    10.7807   -5.0951
            60  O1a O    11.9921   -3.0451
            61  O1a O    10.7807  -22.4273
            62  O1a O     9.6159  -20.3772
BOND        69
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 2
            13    6  14 1
            14    7  15 1
            15    7  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 2
            19   11  20 1
            20   11  21 1
            21   12  22 2
            22   13  23 1
            23   14  24 2
            24   15  25 2
            25   16  26 2
            26   16  27 1
            27   17  28 1
            28   18  29 1
            29   18  30 2
            30   20  31 2
            31   21  32 2
            32   21  33 1
            33   22  34 1
            34   23  35 1
            35   23  36 2
            36   28  37 1
            37   28  38 2
            38   39  29 1 #Up
            39   34  40 1
            40   34  41 2
            41   42  35 1 #Up
            42   39  43 1
            43   39  44 1
            44   42  45 1
            45   42  46 1
            46   43  47 1
            47   44  48 1
            48   44  49 1 #Down
            49   45  50 1
            50   46  51 1
            51   46  52 1 #Down
            52   47  53 1
            53   47  54 1 #Up
            54   48  55 1 #Up
            55   50  56 1
            56   50  57 1 #Up
            57   51  58 1 #Up
            58   53  59 1 #Down
            59   54  60 1
            60   56  61 1 #Down
            61    9  15 1
            62   13  20 1
            63   17  26 1
            64   19  30 1
            65   22  32 1
            66   24  36 1
            67   48  53 1
            68   51  56 1
            69   57  62 1

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