KEGG   DRUG: Dexamethasone acetate
Entry
D02174                      Drug                                   

Name
Dexamethasone acetate (JAN/USP);
Decadronal (TN)
Formula
C24H31FO6. H2O
Exact mass
452.221
Mol weight
452.513
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D02174  Dexamethasone acetate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone acetate
    D02174  Dexamethasone acetate (JAN/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone acetate
    D02174  Dexamethasone acetate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02174  Dexamethasone acetate (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02174
Other DBs
CAS: 55812-90-3
PubChem: 7849235
DrugBank: DB01234
LigandBox: D02174
LinkDB
KCF data

ATOM        32
            1   C2x C    17.7128  -16.5491
            2   C5x C    17.7128  -17.9064
            3   C2x C    18.8882  -18.5850
            4   C2y C    20.0636  -17.9064
            5   C1z C    20.0636  -16.5491
            6   C2x C    18.8882  -15.8705
            7   C1x C    21.2391  -18.5850
            8   C1x C    22.4144  -17.9064
            9   C1y C    22.4144  -16.5491
            10  C1z C    21.2391  -15.8705
            11  C1y C    23.5899  -15.8705
            12  C1z C    23.5899  -14.5132
            13  C1x C    22.4144  -13.8346
            14  C1y C    21.2391  -14.5132
            15  C1x C    25.9407  -15.8705
            16  C1y C    25.9407  -14.5132
            17  C1z C    24.7653  -13.8346
            18  C1a C    20.0636  -15.1918
            19  O1a O    20.0656  -13.8358
            20  C1a C    23.5899  -13.1560
            21  C1a C    27.1036  -13.8417
            22  C5a C    24.7653  -12.1381
            23  X   F    21.2391  -17.2277
            24  O1a O    25.9407  -12.9465
            25  O5x O    16.5375  -18.5850
            26  O5a O    25.9447  -11.4572
            27  C1b C    23.5938  -11.4617
            28  O7a O    22.4368  -12.1299
            29  C7a C    21.2411  -11.4393
            30  C1a C    20.0186  -12.1452
            31  O6a O    21.2419  -10.0104
            32  O0  O    28.9100  -16.8700
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2

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