KEGG   DRUG: Papaverine hydrochloride
Entry
D02218                      Drug                                   

Name
Papaverine hydrochloride (JP17/USP);
Pavabid (TN)
Formula
C20H21NO4. HCl
Exact mass
375.1237
Mol weight
375.846
Structure
Simcomp
Remark
Therapeutic category: 1243
ATC code: A03AD01 G04BE02
Chemical structure group: DG00043
Product (DG00043): D02218<JP>
Product (mixture): D04252<JP> D04299<JP>
Efficacy
Antispasmodic, Smooth muscle relaxant, Vasodilator, Phosphodiesterase inhibitor
Comment
Papaverine derivative
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    A03AD Papaverine and derivatives
     A03AD01 Papaverine
      D02218  Papaverine hydrochloride (JP17/USP) <JP>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BE Drugs used in erectile dysfunction
     G04BE02 Papaverine
      D02218  Papaverine hydrochloride (JP17/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1243  Papaverines
     D02218  Papaverine hydrochloride (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D02218  Papaverine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Papaverine
    D02218  Papaverine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    PDE
     D02218  Papaverine hydrochloride (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02218  Papaverine hydrochloride
  D02218  Papaverine hydrochloride injection
Other DBs
CAS: 61-25-6
PubChem: 7849277
ChEMBL: CHEMBL98123
DrugBank: DB01113
LigandBox: D02218
NIKKAJI: J231.281F
LinkDB
KCF data

ATOM        26
            1   C8y C    22.7751  -18.0380
            2   C8y C    22.7751  -16.6387
            3   C8y C    23.9414  -18.7377
            4   C8x C    21.5624  -18.7377
            5   C8x C    21.5624  -15.9389
            6   C8x C    23.9880  -15.9389
            7   C1b C    23.9414  -20.1371
            8   N5x N    25.2008  -18.0380
            9   C8y C    20.3496  -18.0380
            10  C8y C    20.3496  -16.6387
            11  C8x C    25.2008  -16.6387
            12  C8y C    25.1541  -20.8368
            13  O2a O    19.1368  -18.7377
            14  O2a O    19.1368  -15.9389
            15  C8x C    26.3670  -20.1371
            16  C8x C    25.1541  -22.2363
            17  C1a C    17.9240  -18.0380
            18  C1a C    17.9240  -16.6387
            19  C8y C    27.5797  -20.8368
            20  C8x C    26.3669  -22.9359
            21  C8y C    27.5797  -22.2363
            22  O2a O    28.7926  -20.0905
            23  O2a O    28.7926  -22.8893
            24  C1a C    30.0064  -20.7468
            25  C1a C    29.9669  -22.1638
            26  X   Cl   34.1144  -21.4905
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    9  13 1
            13   10  14 1
            14   12  15 1
            15   12  16 2
            16   13  17 1
            17   14  18 1
            18   15  19 2
            19   16  20 1
            20   19  21 1
            21   19  22 1
            22   21  23 1
            23    8  11 1
            24    9  10 2
            25   20  21 2
            26   22  24 1
            27   23  25 1

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