| Entry |
|
|---|
| Name |
Morphine hydrochloride hydrate (JP17);
Morphine hydrochloride trihydrate;
Anpec (TN)
|
|---|
| Formula |
C17H19NO3. 3H2O. HCl
|
|---|
| Exact mass |
375.1449
|
|---|
| Mol weight |
375.8444
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Therapeutic category: | 8114 |
| Product (DG00810): | D00842<JP/US> D02271<JP> |
|
|---|
| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Other map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA01 Morphine
D02271 Morphine hydrochloride hydrate (JP17) <JP>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Morphine
D02271 Morphine hydrochloride hydrate (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
8 Narcotics
81 Alkaloidal narcotics
811 Opium alkaloids
8114 Morphines
D02271 Morphine hydrochloride hydrate (JP17)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D02271 Morphine hydrochloride hydrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02271 Morphine hydrochloride hydrate
D02271 Morphine hydrochloride tablets
D02271 Morphine hydrochloride injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02271
|
|---|
| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 25
1 X Cl 27.0190 -23.0527
2 O0 O 27.2299 -20.5437
3 C1z C 19.1395 -23.6495
4 C8y C 19.1395 -22.3255
5 C1y C 20.3241 -24.3462
6 C1y C 18.0246 -24.2766
7 C1x C 20.3241 -23.0224
8 C8y C 18.0246 -21.6984
9 C8y C 20.3241 -21.6984
10 C1y C 21.4390 -23.6495
11 C2x C 20.3241 -25.6005
12 O2x O 16.7007 -22.9526
13 C1y C 18.0246 -25.6005
14 C1x C 22.5538 -23.0224
15 C8y C 18.0246 -20.3745
16 C1x C 21.4390 -22.3952
17 C8x C 20.3241 -20.3745
18 N1y N 22.5538 -24.3462
19 C2x C 19.1395 -26.2973
20 O1a O 16.9098 -26.2973
21 C8x C 19.2092 -19.7474
22 O1a O 16.9098 -19.7474
23 C1a C 23.9527 -24.3462
24 O0 O 27.2299 -20.5437
25 O0 O 27.2299 -20.5437
BOND 25
1 3 4 1
2 3 5 1
3 3 6 1
4 3 7 1 #Up
5 4 8 2
6 4 9 1
7 5 10 1
8 5 11 1
9 6 12 1 #Down
10 6 13 1
11 7 14 1
12 8 15 1
13 9 16 1
14 9 17 2
15 10 18 1 #Up
16 11 19 2
17 13 20 1 #Down
18 15 21 2
19 15 22 1
20 8 12 1
21 10 16 1
22 13 19 1
23 14 18 1
24 17 21 1
25 18 23 1
BRACKET 1 25.0600 -21.4200 25.0600 -19.5300
1 27.9300 -19.5300 27.9300 -21.4200
1 3
ORIGINAL 1 2
REPEAT 1 25 26
|
|---|
