KEGG   DRUG: Morphine hydrochloride hydrate
Entry
D02271                      Drug                                   

Name
Morphine hydrochloride hydrate (JP17);
Morphine hydrochloride trihydrate;
Anpec (TN)
Formula
C17H19NO3. 3H2O. HCl
Exact mass
375.1449
Mol weight
375.8444
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 8114
ATC code: N02AA01
Chemical structure group: DG00810
Product (DG00810): D00842<JP/US> D02271<JP>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Other map
map05032  Morphine addiction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA01 Morphine
      D02271  Morphine hydrochloride hydrate (JP17) <JP>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Morphine
    D02271  Morphine hydrochloride hydrate (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8114  Morphines
     D02271  Morphine hydrochloride hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D02271  Morphine hydrochloride hydrate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02271  Morphine hydrochloride hydrate
  D02271  Morphine hydrochloride tablets
  D02271  Morphine hydrochloride injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02271
Other DBs
CAS: 6055-06-7
PubChem: 7849330
ChEBI: 55348
DrugBank: DB00295
LigandBox: D02271
LinkDB
KCF data

ATOM        25
            1   X   Cl   27.0190  -23.0527
            2   O0  O    27.2299  -20.5437
            3   C1z C    19.1395  -23.6495
            4   C8y C    19.1395  -22.3255
            5   C1y C    20.3241  -24.3462
            6   C1y C    18.0246  -24.2766
            7   C1x C    20.3241  -23.0224
            8   C8y C    18.0246  -21.6984
            9   C8y C    20.3241  -21.6984
            10  C1y C    21.4390  -23.6495
            11  C2x C    20.3241  -25.6005
            12  O2x O    16.7007  -22.9526
            13  C1y C    18.0246  -25.6005
            14  C1x C    22.5538  -23.0224
            15  C8y C    18.0246  -20.3745
            16  C1x C    21.4390  -22.3952
            17  C8x C    20.3241  -20.3745
            18  N1y N    22.5538  -24.3462
            19  C2x C    19.1395  -26.2973
            20  O1a O    16.9098  -26.2973
            21  C8x C    19.2092  -19.7474
            22  O1a O    16.9098  -19.7474
            23  C1a C    23.9527  -24.3462
            24  O0  O    27.2299  -20.5437
            25  O0  O    27.2299  -20.5437
BOND        25
            1     3   4 1
            2     3   5 1
            3     3   6 1
            4     3   7 1 #Up
            5     4   8 2
            6     4   9 1
            7     5  10 1
            8     5  11 1
            9     6  12 1 #Down
            10    6  13 1
            11    7  14 1
            12    8  15 1
            13    9  16 1
            14    9  17 2
            15   10  18 1 #Up
            16   11  19 2
            17   13  20 1 #Down
            18   15  21 2
            19   15  22 1
            20    8  12 1
            21   10  16 1
            22   13  19 1
            23   14  18 1
            24   17  21 1
            25   18  23 1
BRACKET     1    25.0600  -21.4200   25.0600  -19.5300
            1    27.9300  -19.5300   27.9300  -21.4200
            1  3
 ORIGINAL  1    2
 REPEAT    1   25  26

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