KEGG   DRUG: Hydrocortisone valerate
Entry
D02288                      Drug                                   

Name
Hydrocortisone valerate (USP);
Westcort (TN)
Product
  Generic
Formula
C26H38O6
Exact mass
446.2668
Mol weight
446.5763
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Hydrocortisone
     D02288  Hydrocortisone valerate (USP)
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D02288  Hydrocortisone valerate (USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D02288  Hydrocortisone valerate (USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D02288  Hydrocortisone valerate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02288  Hydrocortisone valerate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02288
Topical steroids potency [br08317.html]
 Classification in the USA
  D02288
Other DBs
CAS: 57524-89-7
PubChem: 7849347
ChEMBL: CHEMBL1200562 CHEMBL67128
LigandBox: D02288
NIKKAJI: J14.546G
LinkDB
KCF data

ATOM        32
            1   C1y C    15.2600   -7.7700
            2   C1y C    14.0700   -8.4700
            3   C1z C    15.2600   -6.4400
            4   C1x C    17.5700   -7.7700
            5   C1y C    12.8800   -7.7700
            6   C1x C    14.0700   -9.8000
            7   C1z C    16.4500   -5.7400
            8   C1x C    14.0700   -5.7400
            9   C1a C    15.2600   -5.0400
            10  C1x C    17.5700   -6.4400
            11  C1z C    11.6900   -8.4700
            12  C1y C    12.8800   -6.4400
            13  C1x C    12.8800  -10.5000
            14  C5a C    16.4500   -4.3400
            15  C2y C    11.6900   -9.8000
            16  C1x C    10.5000   -7.7700
            17  C1a C    11.6900   -7.0700
            18  O1a O    11.6900   -5.7400
            19  C1b C    17.6400   -3.6400
            20  O5a O    15.2600   -3.6400
            21  C2x C    10.5000  -10.5000
            22  C1x C     9.3100   -8.4700
            23  O1a O    18.8300   -4.3400
            24  C5x C     9.3100   -9.8000
            25  O5x O     8.1200  -10.5000
            26  O7a O    17.6745   -5.0613
            27  C7a C    18.8397   -5.7615
            28  C1b C    20.0658   -5.0820
            29  C1b C    21.2960   -5.8210
            30  C1b C    22.5127   -5.1462
            31  C1a C    23.7480   -5.8876
            32  O6a O    18.8155   -7.1399
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   27  32 2

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