KEGG   DRUG: Erythromycin propionate
Entry
D02525                      Drug                                   

Name
Erythromycin propionate (USAN)
Formula
C40H71NO14
Exact mass
789.4875
Mol weight
789.99
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A inhibitor
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Active form of prodrug: Erythromycin [DR:D00140]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02525  Erythromycin propionate (USAN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02525  Erythromycin propionate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02525  Erythromycin propionate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02525
 Drug transporters
  D02525
Prodrugs [br08324.html]
 D02525
Other DBs
CAS: 134-36-1
PubChem: 17396699
ChEMBL: CHEMBL2220427
DrugBank: DB00199
LigandBox: D02525
NIKKAJI: J5.592A
LinkDB
KCF data

ATOM        55
            1   C1y C    27.5803  -10.5165
            2   C1z C    27.5803   -9.1533
            3   C1y C    26.3962  -11.1924
            4   O2a O    30.1215  -11.5828
            5   C1x C    26.3962   -8.4717
            6   O1a O    28.6084   -8.1656
            7   C1a C    28.8626   -9.5864
            8   C1y C    26.3962  -12.5556
            9   C1a C    25.4255  -10.1707
            10  C1y C    31.3493   -8.8380
            11  C1y C    26.3962   -7.1027
            12  O2a O    27.1356  -13.9130
            13  C1y C    25.2236  -13.2373
            14  C1y C    32.5174   -9.5292
            15  O2x O    31.3613   -7.4753
            16  C5x C    25.2236   -6.4268
            17  C1a C    27.5803   -6.4268
            18  C1y C    28.6516  -14.3309
            19  C7x C    24.0395  -12.5556
            20  C1a C    25.2236  -14.6003
            21  C1y C    33.7729   -8.8676
            22  O7a O    32.5783  -11.7369
            23  C1y C    32.5517   -6.8110
            24  C1y C    24.0395   -7.1027
            25  O5x O    25.2236   -5.0636
            26  C1x C    28.6516  -15.6884
            27  O2x O    29.8358  -13.6494
            28  O7x O    24.0395  -11.1924
            29  O6a O    22.9824  -13.5029
            30  C1x C    33.7173   -7.5100
            31  N1c N    34.8758   -9.5560
            32  C1a C    32.5714   -5.4505
            33  C1y C    24.0395   -8.4717
            34  C1a C    22.8612   -6.4268
            35  C1z C    29.8358  -16.3758
            36  C1y C    31.0082  -14.3309
            37  C1y C    22.8612  -10.5165
            38  C1z C    22.8612   -9.1533
            39  O1a O    25.2236   -9.1533
            40  C1y C    31.0082  -15.6884
            41  O2a O    29.8358  -17.6986
            42  C1a C    31.2798  -17.3578
            43  C1a C    32.1924  -13.6552
            44  C1b C    21.6827  -11.1924
            45  C1a C    21.6135   -9.7192
            46  O1a O    21.6135   -8.4660
            47  O1a O    32.1924  -16.3758
            48  C1a C    30.9332  -18.6575
            49  C1a C    21.7177  -12.3129
            50  C1a C    36.1221   -8.8485
            51  C7a C    33.7745  -12.4386
            52  O6a O    33.7745  -13.8386
            53  C1b C    34.9542  -11.7630
            54  C1a C    36.1447  -12.4561
            55  C1a C    34.8758  -10.9560
BOND        57
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   51  53 1
            56   53  54 1
            57   31  55 1

» Japanese version   » Back

DBGET integrated database retrieval system