KEGG   DRUG: Dexamethasone beloxil
Entry
D02592                      Drug                                   

Name
Dexamethasone beloxil (USAN)
Formula
C29H35FO5
Exact mass
482.2469
Mol weight
482.5836
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02592  Dexamethasone beloxil (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02592
Other DBs
CAS: 150587-07-8
PubChem: 17396763
ChEMBL: CHEMBL2106699
DrugBank: DB01234
LigandBox: D02592
LinkDB
KCF data

ATOM        35
            1   C2x C    16.8028  -16.5491
            2   C5x C    16.8028  -17.9064
            3   C2x C    17.9782  -18.5850
            4   C2y C    19.1536  -17.9064
            5   C1z C    19.1536  -16.5491
            6   C2x C    17.9782  -15.8705
            7   C1x C    20.3291  -18.5850
            8   C1x C    21.5044  -17.9064
            9   C1y C    21.5044  -16.5491
            10  C1z C    20.3291  -15.8705
            11  C1y C    22.6799  -15.8705
            12  C1z C    22.6799  -14.5132
            13  C1x C    21.5044  -13.8346
            14  C1y C    20.3291  -14.5132
            15  C1x C    25.0307  -15.8705
            16  C1y C    25.0307  -14.5132
            17  C1z C    23.8553  -13.8346
            18  C1a C    19.1536  -15.1918
            19  O1a O    19.1556  -13.8358
            20  C1a C    22.6799  -13.1560
            21  C1a C    26.1936  -13.8417
            22  C5a C    23.8553  -11.0181
            23  X   F    20.3291  -17.2277
            24  O1a O    25.0307  -12.9465
            25  O5x O    15.6275  -18.5850
            26  O5a O    25.0347  -10.3372
            27  C1b C    22.6838  -10.3417
            28  O2a O    21.5268  -11.0099
            29  C1b C    20.3311  -10.3193
            30  C8y C    19.1086  -11.0252
            31  C8x C    17.9123  -10.3351
            32  C8x C    16.7001  -11.0355
            33  C8x C    16.7006  -12.4355
            34  C8x C    17.8969  -13.1256
            35  C8x C    19.1091  -12.4252
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 2
            35   31  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   30  35 1

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