KEGG   DRUG: Interferon alfa-2b
Entry
D02745                      Drug                                   

Name
Interferon alfa-2b (USAN);
Interferon alfa-2b (genetical recombination) (JAN);
Intron A (TN)
Product
Formula
C860H1353N229O255S9
Exact mass
19256.7431
Mol weight
19268.9111
Sequence
CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
  Type
Peptide
Class
Antineoplastic
 DG01752  Interferone
Remark
ATC code: L03AB05
Chemical structure group: DG01750
Product (DG01750): D02745<US> D03305<JP> D04553<US>
Efficacy
Antineoplastic, Antiviral, Biological response modifier
  Disease
Hairy cell leukemia [DS:H00006]
Malignant melanoma [DS:H00038]
Follicular lymphoma [DS:H01613]
Condylomata acuminata [DS:H01418]
AIDS-related Kaposi's sarcoma [DS:H00041]
Chronic hepatitis C [DS:H00413]
Chronic hepatitis B [DS:H00412]
Target
IFNAR1 [HSA:3454] [KO:K05130]
IFNAR2 [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
Interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB05 Interferon alfa-2b
      D02745  Interferon alfa-2b (USAN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunostimulants
   Interferons
    Interferon Alfa 2B
     D02745  Interferon alfa-2b (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interferon receptors
    IFNAR1
     D02745  Interferon alfa-2b (USAN) <US>
    IFNAR2
     D02745  Interferon alfa-2b (USAN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02745
Other DBs
CAS: 99210-65-8
PubChem: 47205818
DrugBank: DB00105
LinkDB

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