KEGG   DRUG: Acamprosate calcium
Entry
D02780                      Drug                                   
Name
Acamprosate calcium (JAN/USAN);
Campral (TN);
Regtect (TN)
Product
  Generic
ACAMPROSATE CALCIUM (American Health Packaging), ACAMPROSATE CALCIUM (Glenmark Pharmaceuticals), ACAMPROSATE CALCIUM (Major Pharmaceuticals), ACAMPROSATE CALCIUM (Mylan Pharmaceuticals), ACAMPROSATE CALCIUM (Zydus Lifesciences Limited), ACAMPROSATE CALCIUM (Zydus Pharmaceuticals (USA))
Formula
(C5H10NO4S)2. Ca
Exact mass
400.0287
Mol weight
400.49
Structure
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Remark
Therapeutic category: 1190
ATC code: N07BB03
Chemical structure group: DG00996
Product (DG00996): D02780<JP/US>
Efficacy
Antialcohol dependence, NMDA receptor antagonist
  Disease
Alcohol dependence [DS:H01611]
Comment
Treatment of alcohol dependency
Target
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05034  Alcoholism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BB Drugs used in alcohol dependence
     N07BB03 Acamprosate
      D02780  Acamprosate calcium (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Alcohol Deterrents/Anti-craving
   Acamprosate
    D02780  Acamprosate calcium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02780  Acamprosate calcium (JAN/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01498  NMDA receptor antagonist
   DG00996  Acamprosate
    D02780  Acamprosate calcium
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D02780  Acamprosate calcium (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02780
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02780
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02780
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01498  NMDA receptor antagonist
   DG00996  Acamprosate
Other DBs
CAS: 77337-73-6
PubChem: 17396938
ChEBI: 51042
LigandBox: D02780
NIKKAJI: J309.378F
LinkDB
KCF data

ATOM        23
            1   C1a C    21.6233  -20.9826
            2   C5a C    22.8217  -21.6744
            3   N1b N    24.0200  -20.9826
            4   C1b C    25.2183  -21.6744
            5   C1b C    26.4166  -20.9826
            6   C1b C    27.6150  -21.6744
            7   S4a S    28.8134  -20.9826
            8   O5a O    22.8217  -23.0582
            9   O1d O    30.0258  -21.6827 #-
            10  O1d O    30.0258  -20.2826
            11  O1d O    27.6009  -20.2826
            12  Z   Ca   34.4228  -22.0203 #2+
            13  C1a C    21.6233  -20.9826
            14  C5a C    22.8217  -21.6744
            15  N1b N    24.0200  -20.9826
            16  C1b C    25.2183  -21.6744
            17  C1b C    26.4166  -20.9826
            18  C1b C    27.6150  -21.6744
            19  S4a S    28.8134  -20.9826
            20  O1d O    30.0258  -21.6827 #-
            21  O1d O    30.0258  -20.2826
            22  O1d O    27.6009  -20.2826
            23  O5a O    22.8217  -23.0582
BOND        20
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   8 2
            8     7   9 1
            9     7  10 2
            10    7  11 2
            11   13  14 1
            12   14  15 1
            13   15  16 1
            14   16  17 1
            15   17  18 1
            16   18  19 1
            17   14  23 2
            18   19  20 1
            19   19  21 2
            20   19  22 2
BRACKET     1    19.7400  -24.0100   19.7400  -18.6200
            1    31.0800  -18.6200   31.0800  -24.0100
            1  2
 ORIGINAL  1    1   2   3   4   5   6   7   9  10  11   8
 REPEAT    1   13  14  15  16  17  18  19  20  21  22  23

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