KEGG   DRUG: Aptazapine maleate
Entry
D02972                      Drug                                   

Name
Aptazapine maleate (USAN)
Formula
C16H19N3. C4H4O4
Exact mass
369.1689
Mol weight
369.4143
Structure
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01728  Tricyclic antidepressant
Efficacy
Antidepressant, alpha2-Adrenergic receptor antagonist
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D02972  Aptazapine maleate (USAN)
Other DBs
CAS: 71576-41-5
PubChem: 17397129
ChEMBL: CHEMBL2106459
LigandBox: D02972
NIKKAJI: J400.156G
LinkDB
KCF data

ATOM        27
            1   C8y C    25.8255  -13.7176
            2   C1x C    24.6357  -13.0877
            3   N4y N    23.3059  -13.6476
            4   C8y C    22.9560  -14.9774
            5   C8y C    26.1054  -15.1174
            6   C1y C    23.7958  -16.1671
            7   N1y N    25.1956  -16.1671
            8   C1x C    25.8954  -17.3569
            9   C1x C    25.1956  -18.5467
            10  N1y N    23.7958  -18.5467
            11  C1x C    23.0960  -17.3569
            12  C8x C    26.8753  -12.8077
            13  C8x C    28.2051  -13.2977
            14  C8x C    28.4850  -14.6974
            15  C8x C    27.3652  -15.6073
            16  C8x C    21.5563  -14.9774
            17  C8x C    21.0663  -13.7176
            18  C8x C    22.1862  -12.8777
            19  C1a C    23.0960  -19.8065
            20  O6a O    30.9346  -15.9572
            21  C6a C    32.3343  -15.9572
            22  O6a O    32.9642  -17.1470
            23  C2b C    32.9642  -14.7674
            24  C2b C    34.6439  -14.7674
            25  C6a C    35.3438  -15.9572
            26  O6a O    36.6735  -15.9572
            27  O6a O    34.6439  -17.1470
BOND        29
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11   6 1
            13    1  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17    5  15 1
            18    4  16 2
            19   16  17 1
            20   17  18 2
            21    3  18 1
            22   10  19 1
            23   20  21 1
            24   21  22 2
            25   21  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   25  27 1

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