KEGG   DRUG: Articaine hydrochloride
Entry
D02991                      Drug                                   

Name
Articaine hydrochloride (JAN/USP)
Formula
C13H20N2O3S. HCl
Exact mass
320.0961
Mol weight
320.8354
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Remark
ATC code: N01BB08
Chemical structure group: DG00805
Product (mixture): D11290<US>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB08 Articaine
      D02991  Articaine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN2A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN3A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN4A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN5A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN8A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN9A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN10A
     D02991  Articaine hydrochloride (JAN/USP)
    SCN11A
     D02991  Articaine hydrochloride (JAN/USP)
Other DBs
CAS: 23964-57-0
PubChem: 17397147
ChEMBL: CHEMBL1200819
LigandBox: D02991
NIKKAJI: J369.157H
LinkDB
KCF data

ATOM        20
            1   X   Cl   30.1700  -17.8500
            2   C8y C    18.9700  -17.9900
            3   C8y C    20.4400  -17.9900
            4   C8y C    20.8600  -16.6600
            5   S2x S    19.7400  -15.8200
            6   C8x C    18.5500  -16.6600
            7   N1b N    21.2800  -19.1100
            8   C7a C    22.1900  -16.2400
            9   O6a O    23.1000  -17.0100
            10  O7a O    22.4700  -14.8400
            11  C1a C    23.8000  -14.4200
            12  C1a C    18.1300  -19.1100
            13  C5a C    22.6800  -19.1100
            14  C1c C    23.3800  -20.3224
            15  N1b N    24.7798  -20.3224
            16  O5a O    23.3800  -17.8976
            17  C1a C    22.6896  -21.5179
            18  C1b C    25.4703  -21.5180
            19  C1b C    26.8797  -21.5180
            20  C1a C    27.5677  -22.7095
BOND        19
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     8   9 2
            9     8  10 1
            10   10  11 1
            11    2  12 1
            12    7  13 1
            13   13  14 1
            14   14  15 1
            15   13  16 2
            16   14  17 1
            17   15  18 1
            18   18  19 1
            19   19  20 1

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