KEGG   DRUG: Bortezomib
Entry
D03150                      Drug                                   
Name
Bortezomib (JAN/USAN/INN);
Velcade (TN)
Product
BORTEZOMIB (Dr.Reddy's Laboratories), BORTEZOMIB (Hospira), BORTEZOMIB (MAIA Pharmaceuticals), VELCADE (Takeda Pharmaceuticals America)
  Generic
BORTEZOMIB (Apotex Corp), BORTEZOMIB (Bamboo US Bidco LCC), BORTEZOMIB (Baxter Healthcare Corporation), BORTEZOMIB (BluePoint Laboratories), BORTEZOMIB (BluePoint Laboratories), BORTEZOMIB (BluePoint Laboratories), BORTEZOMIB (Camber Pharmaceuticals), BORTEZOMIB (Dr.Reddy's Laboratories), BORTEZOMIB (Fresenius Kabi USA), BORTEZOMIB (Hikma Pharmaceuticals USA), BORTEZOMIB (Hospira), BORTEZOMIB (Ingenus Pharmaceuticals), BORTEZOMIB (Meitheal Pharmaceuticals), BORTEZOMIB (Novadoz Pharmaceuticals LLC), BORTEZOMIB (Pharmascience), BORTEZOMIB (Qilu Pharmaceutical), BORTEZOMIB (Sagent Pharmaceuticals), BORTEZOMIB (Sandoz), BORTEZOMIB (Sintetica US LLC), BORTEZOMIB (Waverley Pharma), BORTEZOMIB (Zydus Lifesciences Limited), BORTEZOMIB (Zydus Pharmaceuticals USA)
Formula
C19H25BN4O4
Exact mass
384.1969
Mol weight
384.24
Structure
Class
Antineoplastic
 DG03134  Proteasome inhibitor
Remark
Therapeutic category: 4291
ATC code: L01XG01
Chemical structure group: DG03219
Product (DG03219): D03150<JP/US> D12311<JP/US>
Efficacy
Antineoplastic, Proteasome inhibitor
  Disease
Multiple myeloma [DS:H00010]
Mantle cell lymphoma [DS:H01464]
Target
PSMB5 [HSA:5693] [KO:K02737]
  Pathway
hsa03050  Proteasome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XG Proteasome inhibitors
     L01XG01 Bortezomib
      D03150  Bortezomib (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03150  Bortezomib (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG03134  Proteasome inhibitor
   DG03219  Bortezomib
    D03150  Bortezomib
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Threonine peptidases
    PSMB5
     D03150  Bortezomib (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03150
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03150
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03150
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03150
Drug groups [BR:br08330]
 Antineoplastic
  DG03134  Proteasome inhibitor
   DG03219  Bortezomib
Other DBs
CAS: 179324-69-7
PubChem: 17397304
ChEBI: 52717
PDB-CCD: BO2[PDBj]
NIKKAJI: J1.921.292K
LinkDB
KCF data

ATOM        28
            1   N1b N    22.6554  -16.2029
            2   C1c C    23.8603  -15.5194
            3   C8x C    17.8708  -16.2029
            4   C8x C    17.8708  -17.5889
            5   N5x N    19.0679  -18.2854
            6   C8x C    20.2651  -17.5889
            7   C8y C    20.2651  -16.2029
            8   N5x N    19.0679  -15.5134
            9   C5a C    21.4576  -15.5134
            10  O5a O    21.4564  -14.1276
            11  C5a C    25.0492  -16.2179
            12  N1b N    26.2724  -15.5238
            13  C1c C    27.4532  -16.2173
            14  C1b C    28.6374  -15.5453
            15  C1c C    29.7998  -16.2280
            16  C1a C    30.9930  -15.5506
            17  C1a C    29.7895  -17.6043
            18  O5a O    25.0388  -17.6038
            19  C1b C    23.8705  -14.1451
            20  C8y C    25.0967  -13.4488
            21  C8x C    26.2767  -14.1418
            22  C8x C    27.4803  -13.4586
            23  C8x C    27.4905  -12.0748
            24  C8x C    26.3105  -11.3818
            25  C8x C    25.1069  -12.0650
            26  Z   B    27.4430  -18.1578
            27  O1a O    26.2291  -18.8468
            28  O1a O    28.6261  -18.8527
BOND        29
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     8   3 1
            7     7   9 1
            8     9   1 1
            9     2   1 1
            10    9  10 2
            11    2  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   15  17 1
            18   11  18 2
            19   19  20 1
            20   20  21 2
            21   21  22 1
            22   22  23 2
            23   23  24 1
            24   24  25 2
            25   20  25 1
            26    2  19 1 #Up
            27   26  27 1
            28   26  28 1
            29   13  26 1 #Up

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