KEGG   DRUG: Armodafinil
Entry
D03215                      Drug                                   

Name
Armodafinil (USAN/INN);
Nuvigil (TN)
Product
  Generic
Formula
C15H15NO2S
Exact mass
273.0823
Mol weight
273.3501
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01971  Agents for narcolepsy
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
ATC code: N06BA13
Product: D03215<US>
Efficacy
Stimulant (central)
  Disease
Narcolepsy [DS:H01293]
Comment
See Modafinil [DR:D01832]
Target
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA13 Armodafinil
      D03215  Armodafinil (USAN/INN) <US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Wakefulness Promoting Agents
   Armodafinil
    D03215  Armodafinil (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A3 (DAT1)
     D03215  Armodafinil (USAN/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03215
Other DBs
CAS: 112111-43-0
PubChem: 17397368
ChEBI: 77590
ChEMBL: CHEMBL1201192
LigandBox: D03215
NIKKAJI: J2.578.922I
LinkDB
KCF data

ATOM        19
            1   C8x C    14.9817  -17.5728
            2   C8x C    14.9817  -18.9709
            3   C8x C    16.1954  -19.6699
            4   C8x C    17.4021  -18.9709
            5   C8y C    17.4021  -17.5728
            6   C8x C    16.1954  -16.8736
            7   C1c C    18.6134  -16.8746
            8   C8y C    19.8238  -17.5747
            9   C8x C    19.8172  -18.9707
            10  C8x C    21.0276  -19.6708
            11  C8x C    22.2391  -18.9725
            12  C8x C    22.2401  -17.5745
            13  C8x C    21.0296  -16.8745
            14  S4a S    18.6042  -15.4754
            15  C1b C    19.8113  -14.7679
            16  C5a C    19.8019  -13.3689
            17  O3c O    17.3684  -14.7731
            18  O5a O    18.5631  -12.6648
            19  N1a N    21.0008  -12.6658
BOND        20
            1     4   5 1
            2     5   6 2
            3     8   9 2
            4     9  10 1
            5    10  11 2
            6    11  12 1
            7    12  13 2
            8    13   8 1
            9     6   1 1
            10    7  14 1
            11    5   7 1
            12    7   8 1
            13    1   2 2
            14    2   3 1
            15   14  15 1 #Down
            16   15  16 1
            17    3   4 2
            18   14  17 2
            19   16  18 2
            20   16  19 1

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