KEGG   DRUG: Prednisolone valerate acetate
Entry
D03301                      Drug                                   

Name
Prednisolone valerate acetate (JAN);
PDL;
Spirazon (TN)
Formula
C28H38O7
Exact mass
486.2618
Mol weight
486.5971
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D03301  Prednisolone valerate acetate (JAN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D03301  Prednisolone valerate acetate (JAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D03301  Prednisolone valerate acetate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D03301  Prednisolone valerate acetate (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D03301  Prednisolone valerate acetate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone valerate
    D03301  Prednisolone valerate acetate (JAN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone acetate
    D03301  Prednisolone valerate acetate (JAN)
   Prednisolone valerate
    D03301  Prednisolone valerate acetate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03301  Prednisolone valerate acetate (JAN) <JP>
Topical steroids potency [br08317.html]
 Classification in Japan
  D03301
Rx-to-OTC switch list in Japan [br08314.html]
 D03301
Other DBs
CAS: 72064-79-0
PubChem: 17397452
ChEMBL: CHEMBL1697848 CHEMBL66657
DrugBank: DB00860
LigandBox: D03301
NIKKAJI: J67.022G
LinkDB
KCF data

ATOM        35
            1   C2x C    25.7532  -19.2868
            2   C5x C    25.7532  -20.6665
            3   C2x C    26.9481  -21.3564
            4   C2y C    28.1430  -20.6665
            5   C1z C    28.1430  -19.2868
            6   C2x C    26.9481  -18.5969
            7   C1x C    29.3379  -21.3564
            8   C1x C    30.5327  -20.6665
            9   C1y C    30.5327  -19.2868
            10  C1y C    29.3379  -18.5969
            11  C1y C    31.7276  -18.5969
            12  C1z C    31.7276  -17.2172
            13  C1x C    30.5327  -16.5273
            14  C1y C    29.3379  -17.2172
            15  C1x C    34.1173  -18.5969
            16  C1x C    34.1173  -17.2172
            17  C1z C    32.9225  -16.5273
            18  C5a C    32.9225  -14.7286
            19  O7a O    34.1173  -15.8375
            20  C7a C    35.3153  -16.5120
            21  O6a O    35.3454  -17.8829
            22  C1b C    36.4875  -15.8004
            23  C1b C    37.6972  -16.4639
            24  C1b C    38.8604  -15.7579
            25  C1a C    40.0674  -16.4198
            26  C1a C    31.7276  -15.9755
            27  O1a O    28.1450  -16.5285
            28  C1a C    28.1430  -17.9071
            29  O5x O    24.5584  -21.3564
            30  C1b C    34.1300  -14.0313
            31  O5a O    31.6806  -14.0121
            32  O7a O    35.3507  -14.7363
            33  C7a C    36.5480  -14.0456
            34  C1a C    37.7646  -14.7485
            35  O6a O    36.5484  -12.6700
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   17  19 1 #Down
            23   19  20 1
            24   20  21 2
            25   20  22 1
            26   22  23 1
            27   23  24 1
            28   24  25 1
            29   12  26 1 #Up
            30   14  27 1 #Up
            31    5  28 1 #Up
            32    2  29 2
            33   18  30 1
            34   18  31 2
            35   30  32 1
            36   32  33 1
            37   33  34 1
            38   33  35 2

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