KEGG   DRUG: Mometasone furoate hydrateHelp
Entry
D03325                      Drug                                   

Name
Mometasone furoate hydrate (JAN);
Mometasone furoate monohydrate;
Nasonex (TN)
Product
  Generic
Formula
C27H30Cl2O6. H2O
Exact mass
538.1525
Mol weight
539.4448
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1329
ATC code: D07AC13 D07XC03 R01AD09 R03BA07
Chemical structure group: DG00419
Product (DG00419): D00690<JP/US> D03325<JP/US>
Product (mixture): D10295<US>
Efficacy
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC13 Mometasone
      D03325  Mometasone furoate hydrate (JAN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC03 Mometasone
      D03325  Mometasone furoate hydrate (JAN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD09 Mometasone
      D03325  Mometasone furoate hydrate (JAN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA07 Mometasone
      D03325  Mometasone furoate hydrate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Mometasone
     D03325  Mometasone furoate hydrate (JAN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Mometasone
    D03325  Mometasone furoate hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D03325  Mometasone furoate hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03325  Mometasone furoate hydrate (JAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03325
BRITE hierarchy
Other DBs
CAS: 141646-00-6
PubChem: 17397475
DrugBank: DB00764
LigandBox: D03325
LinkDB All DBs
KCF data Show

ATOM        36
            1   O0  O    40.5985  -18.7593
            2   C1z C    32.6900  -17.8500
            3   C1z C    31.5700  -18.5500
            4   C1y C    33.8800  -18.5500
            5   O7a O    34.5800  -16.7300
            6   C5a C    32.6900  -16.5200
            7   C1y C    31.5700  -19.8800
            8   C1x C    30.3800  -17.8500
            9   C1a C    31.5700  -17.1500
            10  C1x C    33.8800  -19.8800
            11  C1a C    35.2100  -18.9000
            12  C7a C    35.9800  -16.7300
            13  C1b C    33.8800  -15.8200
            14  O5a O    31.5000  -15.8200
            15  C1y C    30.3800  -20.5800
            16  C1y C    29.1900  -18.5500
            17  C8y C    36.6100  -15.6100
            18  O6a O    36.6100  -17.9200
            19  X   Cl   33.8800  -14.4200
            20  C1z C    29.1900  -19.8800
            21  C1x C    30.3800  -21.9100
            22  O1a O    28.0700  -17.8500
            23  C8x C    38.0100  -15.6100
            24  O2x O    36.1900  -14.2800
            25  C1z C    28.0700  -20.5800
            26  X   Cl   29.1900  -21.2100
            27  C1x C    29.1900  -22.6100
            28  C8x C    38.4300  -14.2800
            29  C8x C    37.3100  -13.4400
            30  C2y C    28.0700  -21.9100
            31  C2x C    26.8800  -19.8800
            32  C1a C    28.0000  -19.1800
            33  C2x C    26.8800  -22.6100
            34  C2x C    25.6900  -20.5800
            35  C5x C    25.6900  -21.9100
            36  O5x O    24.5000  -22.5400
BOND        39
            1     2   3 1
            2     2   4 1
            3     2   5 1 #Down
            4     2   6 1 #Up
            5     3   7 1
            6     3   8 1
            7     3   9 1 #Up
            8     4  10 1
            9     4  11 1 #Down
            10    5  12 1
            11    6  13 1
            12    6  14 2
            13    7  15 1
            14    8  16 1
            15   12  17 1
            16   12  18 2
            17   13  19 1
            18   15  20 1
            19   15  21 1
            20   16  22 1 #Up
            21   17  23 2
            22   17  24 1
            23   20  25 1
            24   20  26 1 #Down
            25   21  27 1
            26   23  28 1
            27   24  29 1
            28   25  30 1
            29   25  31 1
            30   25  32 1 #Up
            31   30  33 2
            32   31  34 2
            33   33  35 1
            34   35  36 2
            35    7  10 1
            36   16  20 1
            37   27  30 1
            38   28  29 2
            39   34  35 1

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